Letrozole in combination with gonadotropins decreases cancellation rates and improves ongoing pregnancy rates per transfer in poor responders

Kapoor, Monica; Hurwitz, J.M.; Polotsky, Alex J.; Richlin, S.S.; Chi, Ling; Leondires, M.P.

doi:10.1016/j.fertnstert.2007.07.325

Cited by 6 publications

(3 citation statements)

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“…Another explanation of differences between our results versus above-mentioned studies may be attributed to the effects of the two different doses of letrozole used (i.e. 2.5 vs. 5 mg) or the different starting days (32, 33). …”

Section: Discussioncontrasting

confidence: 90%

“…The limitations related to the methodological drawbacks (small study population , lack of randomization, and the different mean age of patients in the compared groups), retrospective nature, and lack of uniform definition for “poor ovarian response”, do not allow to compare the results of these trials and identify firm conclusion (13, 30, 32, 33). …”

Section: Discussionmentioning

confidence: 99%

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Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT

Ebrahimi

Akbari-Asbagh

Ghalandar-Attar

2017

IJRM

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Background:Gonadotropin-releasing hormone (GnRH) antagonist protocol has been proposed as a potentially proper option for the patients with limited ovarian reserve. Nevertheless, there is no significant difference in terms of clinical pregnancy between the GnRH antagonist and agonist cycles. The use of aromatase inhibitors such as letrozole was suggested by some studies. Objective:The object of this study was to evaluate the efficacy of letrozole co-treatment with GnRH-antagonist protocol in ovarian stimulation of poor responder patients undergoing intracytoplasmic sperm injection.Materials and Methods:A double-blinded randomized control trial was conducted on 70 infertile women with poor ovarian response based on Bologna criteria in two groups: letrozole+GnRH-antagonist (LA) group and placebo+GnRH-antagonist (PA) group (n=35/each). The LA group involved at letrozole 2.5 mg daily over 5 days and recombinant human follicle stimulating hormone 225 IU/daily. The PA group received placebo over 5 days and recombinant human follicle stimulating hormone at the same starting day and dose, similar to LA group. GnRH-antagonist was introduced once one or more follicle reached ≥14 mm. The main outcome measures were the number of oocytes retrieved, fertilization rate, implantation rate, cycle cancellation rate, and clinical pregnancy rate.Results:There were no significant differences in demographic characteristics between groups. There were no significant differences between groups regarding the number of oocytes retrieved (p=0.81), number of embryos transferred (p=0.82), fertilization rate (p=0.225), implantation rate (p=0.72), total cycle cancelation rate (p=0.08), and clinical pregnancy rate (p=0.12). Conclusion:The use of letrozole in GnRH-antagonist cycles does not improve clinical outcomes in poor responder patients undergoing intracytoplasmic sperm injection.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT

Ebrahimi

Akbari-Asbagh

Ghalandar-Attar

2017

IJRM

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“…Recently, Kapoor et al (21) evaluated the effect of letrozole in poor ovarian responders. In a small sample size study, 19 patients defined as poor responders based on previous IVF performance were treated with letrozole 5 mg/day on cycle days 2-6.…”

Section: Discussionmentioning

confidence: 99%

Antagonist/letrozole protocol in poor ovarian responders for intracytoplasmic sperm injection: a comparative study with the microdose flare-up protocol

Yaralı́

Esinler

Polat

et al. 2009

Fertility and Sterility

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Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI

Mohsen

Din

2012

Gynecological Endocrinology

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Letrozole in combination with gonadotropins decreases cancellation rates and improves ongoing pregnancy rates per transfer in poor responders

Cited by 6 publications

References 0 publications

Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT

Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT

Antagonist/letrozole protocol in poor ovarian responders for intracytoplasmic sperm injection: a comparative study with the microdose flare-up protocol

Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI

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