Letrozole ovulation induction: an effective option in endometrial preparation for frozen–thawed embryo transfer

Li, Song-jun; Zhang, Yongjing; Chai, Xiaoshan; Nie, Meifang; Zhou, Yuyan; Chen, Jianlin; Tao, Guangshi

doi:10.1007/s00404-013-3044-0

Cited by 48 publications

(52 citation statements)

References 13 publications

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“…Of the four studies included, two are RCTs [60,61] and the remaining two are retrospective cohort studies [53,58]. These data suggest that mild stimulation with either Gn or AI may overcome subtle defects in folliculogenesis, potentially correct luteal phase, and hence improve endometrial receptivity.…”

Section: Discussionmentioning

confidence: 96%

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Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Yaralı́

Polat

Mümüşoğlu

et al. 2016

J Assist Reprod Genet

109

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Purpose The purpose of this study was to evaluate the best protocol to prepare endometrium for frozen embryo replacement (FER) cycles. Methods This study is a systematic review and meta-analysis. Following PubMed and OvidSP search, a total of 1166 studies published after 1990 were identified following removal of duplicates. Following exclusion of studies not matching our inclusion criteria, a total of 33 studies were analyzed. Primary outcome measure was live birth. The following protocols, including true natural cycle (tNC), modified natural cycle (mNC), artificial cycle (AC) with or without suppression, and mild ovarian stimulation (OS) with gonadotropin (Gn) or aromatase inhibitor (AI), were compared. Results No statistically significant difference for both clinical pregnancy and live birth was noted between tNC and mNC groups. When tNC and AC without suppression groups are compared, there was a statistically significant difference in clinical pregnancy rate in favor of tNC, whereas it failed to reach statistical significance for live birth. When tNC and AC with suppression groups are compared, there was a statistically significant difference in live birth rate favoring the latter. Similar pregnancy outcome was noted among mNC versus AC with or without suppression groups. Similarly, no difference in clinical pregnancy and live birth was noted when ACs with or without suppression groups are compared. Conclusions There is no consistent superiority of any endometrial preparation for FER. However, mNC has several advantages (being patient-friendly; yielding at least equivalent or better pregnancy rates when compared with tNC and AC with or without suppression; may not require LPS). Mild OS with Gn or AI may be promising.

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Section: Discussionmentioning

confidence: 96%

“…A total of four studies, two RCTs [60,61] and two retrospective cohort studies [53,58], making a total of 1850 ET cycles, were included.…”

Section: Ac (With or Without Suppression) Versus Mild Os With Gn Or Amentioning

confidence: 99%

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Yaralı́

Polat

Mümüşoğlu

et al. 2016

J Assist Reprod Genet

109

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“…1 No remarkable differences were noted regarding endometrial thickness and clinical pregnancy rates between patients undergoing HRT or natural cycling. 17 Various cycle regimens for FET, including natural ovulatory cycle, artificial cycle and ovulation induction cycles using clomiphene citrate or gonadotrophins, were compared in a Cochrane review, and there was no significant difference in the pregnancy outcome among different cycle regimens.…”

Section: Discussionmentioning

confidence: 95%

“…Common strategies for this purpose involve ovulation induction cycling, hormone replacement therapy (HRT) cycling and natural cycling. 1,2 Frozen-thawed embryo transfer can be accomplished during a natural cycle after spontaneous ovulation or after artificial preparation of endometrium with exogenous steroids. Since the natural cycle protocol does not necessitate administration of exogenous hormones, it is still preferred by many patients.…”

Section: Is There a Difference Betweenmentioning

confidence: 99%

“…Turkiye Klinikleri J Gynecol Obst 2017;27(1): [1][2][3][4][5][6][7] women: Group 1 was composed of 101 women (41.8%) to receive FET after a natural cycle, whereas Group 2 consisted of 143 women (58.2%) that underwent HRT prior to FET. Participants in Group 1 had ultrasound assessment between 10 th and 13 th days of their cycle to evaluate follicular growth and endometrial thickness.…”

Section: Study Populationmentioning

confidence: 99%

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Is There a Difference Between Clinical Outcomes of the Spontaneous Natural Cycle and Hormone Replacement Treatment in Frozen-Thawed Human Embryo Transfer?

Aydin¹,

Aksoy²,

Karadağ³

et al. 2017

Turkiye Klinikleri J Gynecol Obst

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Frozen-thawed embryo transfer can be accomplished during a natural cycle after spontaneous ovulation or after artificial preparation of endometrium with exogenous steroids. The implantation, pregnancy and live birth rates following frozen-thawed embryo transfer (FET) were compared between in a natural and hormonal control cycle. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This single-center, retrospective trial was implemented on data derived from a series of 244 women who had successful FET in our tertiary care center between January 2012 and June 2015. Two groups were constituted: Group 1 consisted of 101 women who underwent FET after spontaneous ovulation; while 143 women had FET after endometrial preparation with hormone replacement therapy. Rates of implantation, clinical pregnancy, and live birth were compared between two groups. R Re e--s su ul lt ts s: : Two groups were similar on baseline characteristics (maternal ages at time of freezing and transfer of embryos, the number of previous fresh and frozen embryo transfer cycles, the number of oocytes and mature oocytes obtained in natural cycles) (p>0.05). There was no difference between 2 groups regarding rates of clinical pregnancy (p=0.13), implantation (p=0.19) and live birth (p=0.26). C Co on nc cl lu us si io on n: : The findings of this study indicated that the clinical outcomes were comparable between the spontaneous natural cycle and hormone replacement treatment in FET.K Ke ey yw wo or rd ds s: : Embryo transfer; embryo implantation; pregnancy rate; live birth; hormone replacement therapy Ö ÖZ ZE ET T A Am ma aç ç: : Dondurulmuş-çözülmüş embriyo transferi ovulasyon sonrası doğal siklus veya endometriyumun dışarıdan steroidler ile hazırlanması sonrası gerçekleştirilebilir. Doğal siklus ve hormonal kontrollü siklus arasında dondurulmuş-çözülmüş embriyo transferi sonrası implantasyon, gebelik ve canlı doğum oranları karşılaştırıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu tek merkezli, retrospektif çalışma bizim üçüncü basamak merkezimizde, Ocak 2012-Haziran 2015 tarihleri arasında başarılı şekilde donmuş embriyo transferi yapılmış olan 244 hasta verisinden gerçekleştirildi. Çal-ışmada 2 grup oluşturuldu: Grup 1 spontan ovulasyon sonrası donmuş embriyo transferi yapılmış olan 101 kadını içerirken; Grup 2 hormonal replasman tedavisi ile endometriyal hazırlık sonrası donmuş embriyo transferi yapılan 143 hastayı içermektedir. Gruplar implantasyon, klinik gebelik ve canlı doğum oranları açısından karşılaştırıldı. B Bu ul lg gu ul la ar r: : Temel özellikler açısından iki grup birbirine benzerdi (embriyo dondurma ve embriyo transferi sırasındaki maternal yaş, önceki taze ve dondurulmuş embriyo transfer siklus sayısı, doğal sikluslarda elde edilen oosit ve olgun oosit sayıları) (p>0,05). İki grup arasında klinik gebelik (p=0,13), implantasyon (p=0,19) ve canlı doğum (p=0,26) oranları açısından fark yoktu. S So on nu uç ç: : Bu çalışmanın bulguları dondurulmuş embriyo ...

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Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

Glujovsky¹,

Pesce

Sueldo

et al. 2020

Cochrane Database of Systematic Reviews

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Letrozole ovulation induction: an effective option in endometrial preparation for frozen–thawed embryo transfer

Cited by 48 publications

References 13 publications

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Is There a Difference Between Clinical Outcomes of the Spontaneous Natural Cycle and Hormone Replacement Treatment in Frozen-Thawed Human Embryo Transfer?

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

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