Letrozole versus Gonadotropins for Ovulation Induction in Clomiphene Citrate Resistance: A Randomized Controlled Study

Abstract

Background: Clomiphene citrate resistance (CCR) occur in 15 -40% in women with PCOS. Several studies have shown that letrozole is superior to CC regarding side effects, ovulation, and pregnancy rates. Letrozole or gonadotropins use for ovulation induction in CCR is not well established which is superior and most safe.Aims: To compare between letrozole and gonadotropin in induction of ovulation in clomiphene citrate resistant cases.