Letter by Babu et al Regarding Article, “Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension”

Effects of Exercise Training on Exercise Capacity in Pulmonary Arterial Hypertension: A Systematic Review of Clinical Trials

“…[18,23,32] All this information supports the argument on the potential benefits for exercise training as an adjunct to existing medical therapies. [36,37] Though implementation requires higher quality evidence.…”

Effects of home-based exercise training on functional outcomes and quality of life in patients with pulmonary hypertension: A randomized clinical trial

“… 6 , 8 , 9 , 10 , 11 However, many of the studies included in these reviews are limited by the generalizability of their findings and models of delivery. 11 , 12 , 13 In addition, the use of a home-based model, which has been found to be as equally effective as a supervised exercise program in cardiac rehabilitation, 14 has not yet been studied extensively in PH. One study by Inagaki et al, 15 which studied the effects of an unsupervised 12-week endurance and strength training program on eight patients with group IV PH, found a 33-m improvement in 6-min walk distance (6MWD) along with improved quality of life (QoL).…”

DDCI‐01, a novel long acting phospdiesterase‐5 inhibitor, attenuated monocrotaline‐induced pulmonary hypertension in rats

“…PH is the consequence of an increase in PVR due to remodeling of the small distal pulmonary arteries and arterioles, causing adaptive RVH, right heart failure. 31 In the present study, RV/(LV + S) was considered the RVH index. In addition, the effects of DDCI-01 on RV(/LV + S) were dose-dependent.…”