Letter: Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature

Rahman, Raphia; Rahman, Sabrina; Ghani, Hira; Rahman, Moshiur

doi:10.1093/neuros/nyab260

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Avian paramyxoviruses (family Paramyxoviridae; also known as avian avulavirus) are a highly diverse group of zoonotic, negative sensed, single stranded RNA viruses detected in a variety of domestic and wildlife species. Avian paramyxoviruses (APMV) range in genomes sizes from 13-17 kilobases (kb) long comprising 20 unique subtypes or serotypes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) classified into three distinct genera according to the International Committee on Taxonomy of Viruses: metaavulavirus (serotypes -2, 5,6,7,8,10,11,14,15,20); orthoavulavirus (serotypes -1, 9, 12,13,16,17,18,19); and paraavulavirus (serotypes -3, 4). Among these species of viruses is avian orthoavulavirus serotype 1 (APMV-1) that commonly induces Newcastle disease [1].…”

Section: Introductionmentioning

confidence: 99%

“…APMV of different serotypes is commonly isolated from poultry and other domesticated birds, however, other wildlife hosts have been described [5][6][7][8][9][10][11]. APMV-1 is the most diverse of the serotypes and is classified into two distinct classes (class I or class II) and further characterized into either 1 genotype (class I) or 15 genotypes (class II) [8].…”

Section: Introductionmentioning

confidence: 99%

“…Similar to other RNA viruses (e.g. AIV) the introduction of APMV to naïve populations is thought to be transmitted from wild migratory birds [6,7,8,10]. Horizontal transmission occurs through oropharyngeal and fecal secretions thus resulting in an easy route for species to contract infection.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of Avian Paramyxoviruses APMV-1 and APMV-6 in Shorebirds and Waterfowl in Southern Ukraine

Klink¹,

Rula²,

Bezymennyi³

et al. 2022

Preprint

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Emerging RNA virus infections are a growing concern among domestic bird and poultry industries due to the severe impact it can have on the flock health and economic livelihoods. Avian paramyxoviruses (APMV) are pathogenic, negative sense RNA viruses that cause serious infections in the respiratory and central nervous system. APMV was detected in multiple avian species during the 2017 migration season in Ukraine, and studied using PCR, virus isolation, and sequencing. Of the 4090 wild bird samples, eleven swabs were isolated in chicken embryos and identified for APMV serotype by hemagglutinin inhibition test: APMV-1, APMV-4, APMV-6, APMV-7. At a variety of sites in Ukraine we characterized the virulence of the virus and further analyzed and predicted the potential risks of spillover to immunologically naïve populations. RNA was extracted and amplified using a multiplex-tiling primer approach to encompass full cDNA genomes. Full-length APMV-1 (n=5) and APMV-6 (n=2) genomes were sequenced on an Oxford Nanopore MinION device in Ukraine. All APMV-1 and APMV-6 fusion (F) proteins possessed a monobasic cleavage site, suggesting these APMV were likely low virulence, annually circulating strains. Utilization of this low-cost method will identify gaps in viral evolution and circulation in this understudied but important critical region for Eurasia.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Discovery of Avian Paramyxoviruses APMV-1 and APMV-6 in Shorebirds and Waterfowl in Southern Ukraine

Klink¹,

Rula²,

Bezymennyi³

et al. 2022

Preprint

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In Reply: Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature

2021

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To the Editor:The authors 1 raise an important point regarding the type of change that can and should be considered when determining the minimal clinically important difference (MCID) for a treatment and patient population. Although the primary examples highlighted in our publication 2 focused on absolute values for the individual patient reported outcome measures (PROMs), percent change can also be used as an MCID. As noted, this can increase an MCID's sensitivity, particularly for patients who score at the extremes of an outcome measure. 3,4 However, anchoring patient satisfaction to an arbitrarily chosen percent change overlooks the "minimal" in MCID. Had the receiver operating characteristic (ROC) curve been run across the continuum, the MCID might have been 25%, or even 35%. The spinal cord stimulation literature, which long has referenced an arbitrary benchmark of 50% pain reduction, exemplifies the need to identify the appropriate threshold that connotes treatment value. 5 For the benefit of our patients, it remains important to find a balance between disease-specific PROMs and neurosurgical PROMs. Disease-specific PROMs such as the Health-Related Quality of Life Measure for Children with Epilepsy (CHEQoL) bring the patient's daily concerns, such as a child's fear of being treated differently, to the surgeon's attention in a way that neurosurgical-specific PROMs may not. 6 Similarly, the Chicago Chiari Outcomes Score (CCOS) is a neurosurgeryspecific PROM that incorporates the impact of complications on patient outcome-a connection that may not be obvious to patients. 7 As a field, we do not want to be short-sighted and trade one set of limitations for another. Rather, using and developing the appropriate complement of PROMs for specific neurosurgical situations will best serve our patients in the future.Access to full text was obtained through Henry Ford Health Systems library resources.

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Letter: Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature

Cited by 2 publications

References 8 publications

Discovery of Avian Paramyxoviruses APMV-1 and APMV-6 in Shorebirds and Waterfowl in Southern Ukraine

Discovery of Avian Paramyxoviruses APMV-1 and APMV-6 in Shorebirds and Waterfowl in Southern Ukraine

In Reply: Contemporary Analysis of Minimal Clinically Important Difference in the Neurosurgical Literature

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