Letter: Covid‐19, and vitamin D

Abstract

LINKED CONTENT This article is linked to Tian et al and Tian and Rong papers. To view these articles, visit https://doi.org/10.1111/apt.15731 and https://doi.org/10.1111/apt.15764.

Editorial: low population mortality from COVID‐19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity

“…Much of the focus has appropriately been on the potential impact of immuno‐modulating therapies. We would also like to highlight the potential importance of nutrition and particularly vitamin D as raised by Panarese and Shahini 2 …”

“…It is becoming clear that countries in the Southern Hemisphere are seeing a relatively low mortality (Figure 1 and Table 1). 2,3 It could be argued that the virus spread later to the Southern Hemisphere and that countries there are simply behind those in the Northern Hemisphere but as time goes by this argument looks increasingly weak. In Australia, 100 cases were reported by 10th March, 1000 by 21st March; in the UK, the first 100 had been reported by 5th March and the first 1000 by 14th March, just 1 week earlier.…”

25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2

“…Recently, some articles have suggested the possible involvement of vitamin D in reducing the risk of respiratory tract infections, especially in the influenza and COVID-19 context. Furthermore, the role of vitamin D supplementation in reducing the risk of infection [3][4][5][6] is still under investigation, however, no clinical evidence has been reported yet.…”

Letter: does vitamin D have a potential role against COVID‐19? Authors' reply

“…We thank Kumar et al for their comments on our review article and the letter connected with that by Panarese and Shahini. 1,2 We agree that there is a complicated effect of vitamin D in preventing the severity of COVID-19, while this mechanism is not exactly the same as that of influenza.…”

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Editors,We thank Kumar et al for their comments on our review article and the letter connected with that by Panarese and Shahini. 1,2 We agree that there is a complicated effect of vitamin D in preventing the severity of COVID-19, while this mechanism is not exactly the same as that of influenza.Vascular injuries have become a focus of attention in COVID-19, especially in its severity and mortality; major risk factors include hypertension, diabetes and age. ACE2 is widely expressed in arterial and venous endothelial cells and arterial smooth muscle cells.

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