Letter: Early detection of growth hormone deficiency.

To clarify the eŠectiveness and safety of azathioprine (AZA) and 6-mercaptopurine (6MP) in the induction and maintenance of remission in ulcerative colitis (UC) by using a systematic review of published studies. References from published studies and reviews were also obtained. Randomized, placebo-controlled trials of oral AZA or 6MP therapy in adult patients with active or quiescent UC were included. Ratios for the induction and maintenance of remission, the steroid-sparing eŠect, and the incidence of adverse drug reactions (ADRs) were compared and evaluated between the two study arms and expressed by the odds ratio (OR) speciˆc for the individual studies and the meta-analytic summary for the OR. We couldˆnd no randomized controlled trial for 6MP therapy. However, four clinical trials for AZA therapy were included in this meta-analysis. For the induction of remission, the pooled OR of the response to AZA therapy compared with placebo in active UC was 1.45 (95％ Conˆdence Interval (CI): 0.68 to 3.08). For the maintenance of remission, the pooled OR for AZA therapy was 2.26 (95％ CI: 1.27 to 4.01). The number needed to treat (NNT) to prevent one recurrence was 6 patients. The pooled OR for AZA therapy's ADRs compared with placebo was 2.11 (95％ CI: 0.92 to 4.84). From the viewpoint of eŠective-ness and safety, this meta-analysis suggests that AZA might be useful in the maintenance of remission in UC patients.

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A Systematic Review of the Clinical Effectiveness of Azathioprine in Patients with Ulcerative Colitis

Ohno

Masunaga

Ogawa

et al. 2004

YAKUGAKU ZASSHI

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Letter: Early detection of growth hormone deficiency.

Abstract: Correspondents are urged to write briefly so that readers may be offered as wide a selection of letters as possible. So many are being received that the omission of some is inevitable. Letters should be signed personally by all their authors.

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A Systematic Review of the Clinical Effectiveness of Azathioprine in Patients with Ulcerative Colitis

A Systematic Review of the Clinical Effectiveness of Azathioprine in Patients with Ulcerative Colitis

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