A general mathematical model is presented for predicting the concentrations of chemically-reactive compounds in indoor air. The model accounts for the effects of ventilation, filtration, heterogeneous removal, direct emission, and photolytic and thermal chemical reactions. The model is applied to the induction of photochemically-reactive pollutants into a museum gallery and the predicted NO, NOx-NO, and 0:5 concentrations are compared to measured data. The model predicts substantial production of several species due to chemical reaction, including HN0 2 , HNOJ, NOJ, and N 2 Qs. Circumstances in which homogeneous chemistry may assume particular importance are identified and include buildings with glass walls, indoor combustion sources. and direct emission of olefins.