2021
DOI: 10.1007/s12015-021-10297-6
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Letter: Glioblastoma Cell of Origin

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Cited by 5 publications
(2 citation statements)
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“…Gliomas are primary brain tumours. Recent data indicate that these tumours are derived from neural stem cells (NSCs), NSC-derived astrocytes, and oligodendrocyte precursor cells (OPCs) [ 86 ]. In the CNS, there are three types of glial cells: astrocytes, oligodendrocytes, and microglia.…”
Section: Gliomasmentioning
confidence: 99%
“…Gliomas are primary brain tumours. Recent data indicate that these tumours are derived from neural stem cells (NSCs), NSC-derived astrocytes, and oligodendrocyte precursor cells (OPCs) [ 86 ]. In the CNS, there are three types of glial cells: astrocytes, oligodendrocytes, and microglia.…”
Section: Gliomasmentioning
confidence: 99%
“…The GBM cell origin is still characterized by lack of consensus among researchers, and grounded two distinct theories, namely the astrocytes de-differentiation and stem cell theory. The astrocytes de-differentiation theory claims that GBM originates from mature astrocytes that suffer driving mutations along the time and return to a more primitive and pluripotent state, with capacity to proliferate and give rise to heterogeneous progeny; on the other hand, the stem cell theory claims that GBM originates from stem cells of the subventricular zone (SVZ) that suffer malignant transformations and possess neurogenesis ability (Habib et al, 2022). The TME of GBM is vast in regard to cell constituents, cell-cell/ cell-extracellular matrix (ECM) interactions and function, thus leading to a tumoral organization into three typical niches-perivascular, hypoxic and invasive (Figure 1) (Hambardzumyan & Bergers, 2015).…”
Section: Gbm Niches Key Cell Players and Tmementioning
confidence: 99%