Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults

Talley, Nick; Holtmann, Gerald; Southwell, Bridget R.; Fisher, David E.; Koloski, Natasha A.; Jones, Michael

doi:10.1111/apt.16877

Cited by 3 publications

(2 citation statements)

References 9 publications

(6 reference statements)

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“…3). A proof-of-concept study using a tailored TENS device demonstrated improvements in symptoms and quality of life, although completion rates were low and device tolerability might be an issue [32,33]. Transabdominal interferential electrical stimulation, a varied form of TENS therapy, also demonstrated improved bowel pattern compared with sham stimulation in women with refractory constipation [34].…”

Section: Nonpharmacological Treatmentsmentioning

confidence: 99%

Step on the accelerator: modern treatment of constipation

Staursky,

Shimoga,

Sharma

2023

Current Opinion in Gastroenterology

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Purpose of review This review aims to explore effective management of constipation, examine challenges in making a positive diagnosis, and highlights the significance of a positive patient-provider relationship and emerging treatments. Recent findings Less than one-fifth of patients feel satisfied with treatment of their constipation. Sixty percent of patients with functional dyspepsia and gastroparesis have severe to very severe constipation that correlates with their upper gastrointestinal symptom severity. Two gold kiwifruits are noninferior to 10 g of psyllium in the treatment of constipation. More than 40% of patients undergoing lumbar fusion continue to fill opioid prescriptions 90 days after surgery, contributing to 80 000 chronic opioid users annually. Most patients are using over-the-counter (OTC) treatments for constipation with greater than 60% dissatisfied. Pharmacologic management involves the use of GCC agonists and emerging drug classes such as bile acid transport inhibitors and sodium hydrogen exchanger isoform 3 (NHE3) inhibitors. Nonpharmacologic treatments, including neuromodulation and FDA-approved vibrating capsule, show promise in improving symptoms and quality of life. Summary Constipation significantly impacts patients’ quality of life and well being and the majority of patients are refractory to conservative measures and OTC treatments. Both pharmacologic and nonpharmacologic treatments hold promise for improving constipation and quality of life.

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Section: Nonpharmacological Treatmentsmentioning

confidence: 99%

Step on the accelerator: modern treatment of constipation

Staursky,

Shimoga,

Sharma

2023

Current Opinion in Gastroenterology

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“…2 We commend Talley et al on their efforts in expanding treatment options for constipation. 3 They describe their promising experience using a non-invasive TENS device in a proof-of-principle study by treating 20 patients with chronic constipation. They found significant improvements in symptoms and quality of life, using an 8-electrode belt that delivers high-frequency, low-intensity stimulation on the abdomen, daily for 16 weeks.…”

mentioning

confidence: 99%

Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults. Authors’ reply

Sharma

Rao

2022

Aliment Pharmacol Ther

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Nearly half of patients with chronic constipation are dissatisfied with traditional treatment options. 1 Our review article on constipation disorders briefly mentioned sacral nerve stimulation(SNS). 2 We commend Talley et al on their efforts in expanding treatment options for constipation. 3 They describe their promising experience using a non-invasive TENS device in a proof-of-principle study by treating 20 patients with chronic constipation. They found significant improvements in symptoms and quality of life, using an 8-electrode belt that delivers high-frequency, low-intensity stimulation on the abdomen, daily for 16 weeks. Only 12/20 (60%) subjects completed the study and it is unclear whether subjects were lost to follow-up or had issues with device tolerability. Nonetheless, we are encouraged by their results and look forward to future sham-controlled, randomised studies that evaluate efficacy with the FDA-endpoint of complete spontaneous bowel movements (CSBMs) per week.

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Phytotherapie, Yoga und Akupunktur in der Gastroenterologie – alles nur Humbug oder mögliche Therapieansätze?

Schreiner,

Bauerfeind

2023

Schweiz. Gastroenterol.

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ZusammenfassungKomplementärmedizinische Therapien werden von Patienten mit gastrointestinalen Beschwerden, insbesondere bei Patienten mit Reizdarmsyndrom („irritable bowel syndrome“, IBS) und bei Patienten mit chronisch-entzündlichen Darmerkrankungen (CED), häufig verwendet. Im Gegensatz zum großen Interesse der Patienten ist das Wissen über solche Therapien bei vielen Gastroenterologen, wahrscheinlich bedingt durch die eher schwache Datenlage, meistens gering. In diesem Übersichtsartikel möchten wir die wichtigsten phytotherapeutischen Therapiemöglichkeiten bei IBS und CED beleuchten und versuchen, einen Überblick über die Datenlage von Bewegungstherapien, Yoga und Akupunktur in der Therapie von gastrointestinalen Krankheiten zu geben.

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Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults

Abstract: to take aseptic biopsies (US 20150320407 A1). B.R. Southwell was an advisor to GI Therapies (the company producing the prototype electrical stimulation device) and holds patents for electrical stimulation devices and methods. She has been funded by the Murdoch Children's

Cited by 3 publications

References 9 publications

Step on the accelerator: modern treatment of constipation

Step on the accelerator: modern treatment of constipation

Letter: non‐invasive transabdominal stimulation device for the treatment of chronic constipation—proof‐of‐principle study in adults. Authors’ reply

Phytotherapie, Yoga und Akupunktur in der Gastroenterologie – alles nur Humbug oder mögliche Therapieansätze?

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