difference appears to be much lower than the mentioned mean difference, with an approximate value of 0.04 logMAR (Fig. 1
of this letter).No doubt that new parameters like subclinical edema detection based on tomographic findings, as shown by Friedrich et al, or the already-mentioned new AI-based software, will pave the way toward better understanding and treating FECD. 1,3 These quantitative tools will also be very useful to monitor responses of the cases when new medical treatments of endothelial diseases become available. 5