Letter: the coeliac stomach – a significant increase in tissue transglutaminase antibodies is associated with gastritis

Therrien, Amélie; Bernard, G; Hétu, Pierre-Olivier; Bouin, Mickaël

doi:10.1111/apt.14029

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Interestingly, the cases with gastritis had higher antibody titers regardless of the extent of villous atrophy. The article suggested that this could be due to having a longer duration of the disease or a potential role of gastric mucosa in gluten-mediated immune reactions (13). In our study, among 39 patients with positive celiacspecific antibodies, 27 were histopathologically proven CD, and all of these patients had chronic gastritis.…”

Section: Celiacmentioning

confidence: 52%

Chronic Gastritis in Pediatric Patients; Helicobacter Pylori or Celiac Disease?

Sandal

2024

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: We aimed to determine the frequency of Celiac disease (CD) and Helicobacter pylori (Hp) infection, and the effect of Hp and chronic gastritis on patients with false positive CD serology in our center. Material and Methods: We included 194 patients who had both stomach and small intestine biopsies and were diagnosed with chronic gastritis, between January 2021 and December 2022 in the study. Patients were divided into two groups: Hp- positive and Hp-negative. Additionally, we evaluated the frequency and association of Hp in cases who were serologically suspected with CD but whose biopsies were not compatible with celiac disease histopathologically. Results: Helicobacter pylori infection was detected in 76 of 194 gastric biopsies examined (39.1%). Hp positivity was detected in only 15 of 27 patients (55.5%) diagnosed with CD and CD serology was positive in 39 of 194 patients (20.1%), but histopathological changes compatible with CD were detected in only 27 (13.9%). Conclusion: Although the relationship between chronic gastritis and Hp is clear, the relationship between Hp and CD remains unclear. We believe that studies with larger patient groups investigating Hp virulence and its effect on CD pathophysiology are needed to reveal this relationship.

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Section: Celiacmentioning

confidence: 52%

Chronic Gastritis in Pediatric Patients; Helicobacter Pylori or Celiac Disease?

Sandal

2024

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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“…Furthermore, AAG has been associated with other autoimmune diseases, particularly autoimmune thyroid diseases [5-7], type I diabetes mellitus [8, 9], vitiligo [10], Addison disease [11], and presumably also coeliac disease (CeD) [12, 13]. Interestingly, some recent studies reported that patients with CeD present alterations of gastric histology and gastric function [14, 15], describing a correlation between gastric mucosal changes and the presence of anti-transglutaminase antibodies [16]. Miceli and colleagues [12] found a 9.1% prevalence of CeD amongst patients affected by AAG, while the figure was much smaller in Kalkan’ s experience (3.4%) [17].…”

Section: Introductionmentioning

confidence: 99%

Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation

et al. 2020

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Background and Aim: Autoimmune atrophic gastritis (AAG) is characterized by a variable spectrum of gastric and extra-gastric symptoms and has been associated with other autoimmune diseases. It is still unknown whether AAG patients have a higher risk of coeliac disease (CeD) or of any other particular duodenal histological damage. Our study aimed at evaluating the duodenal histological findings and the risk of CeD in patients with AAG, with and without other concurrent autoimmune diseases. Methods: We retrospectively collected all the histological findings of the adult patients undergoing upper gastrointestinal endoscopy with concurrent duodenal and gastric biopsies at our gastroenterology unit between 2015 and 2018 and who were regularly followed up at our centre. Date of endoscopy evaluation, endoscopy indication, data on previous CeD diagnosis and on other autoimmune-associated diseases, and a description of histological diagnosis were recorded. Results: Of the 2,423 evaluated endoscopies, 209 patients had an AAG diagnosis (8.6%). One hundred thirty-nine patients, aged 57.4 (standard deviation 13.2) years, were regularly followed up at our centre and were included. Of them, 4 subjects had a previous diagnosis of CeD and one had CeD diagnosis at index endoscopy. Additionally, 8 patients had an isolated increase of intraepithelial lymphocytes (IELs, 6%) and 2 villous atrophy with a normal IEL count. The risk of CeD in AAG was not modulated by the presence of other concurrent autoimmune diseases. Conclusions: We support the screening of all AAG patients with CeD autoantibodies. Findings of isolated IEL or villous atrophy are not exclusively related to CeD.

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Culture of gastric biopsies in celiac disease and its relationship with gastritis and Helicobacter pylori infection

Borghini

Donato

Marino

et al. 2018

Digestive and Liver Disease

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Letter: the coeliac stomach – a significant increase in tissue transglutaminase antibodies is associated with gastritis

Abstract: Linked ContentThis article is linked to Banaszkiewicz et al paper. To view this article visit https://doi.org/10.1111/apt.13789.

Cited by 4 publications

References 9 publications

Chronic Gastritis in Pediatric Patients; Helicobacter Pylori or Celiac Disease?

Chronic Gastritis in Pediatric Patients; Helicobacter Pylori or Celiac Disease?

Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation

Culture of gastric biopsies in celiac disease and its relationship with gastritis and Helicobacter pylori infection

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