Letter to editor: Case report of long COVID-19 with psychosis in a child

Desai, Shivani S; Nguyen, Ashley L.; Bernstein, Gail A.

doi:10.1016/j.psychres.2022.114743

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…These complications often differ from the clinical course expected with a primary psychiatric disorder, can vary in duration of illness, have overlapping symptoms from multiple psychiatric disorders, and, therefore, do not follow well-known treatment guidelines. It has also been observed that a COVID-19 infection may also exacerbate an existing psychiatric disorder or symptoms [3][4][5][6][7]. We report the yearlong course of a previously healthy 16-year-old male who developed persistent symptoms of obsessive-compulsive disorder (OCD) and psychosis following a confirmed COVID-19 infection and subsequent reinfection.…”

Section: Introductionmentioning

confidence: 94%

“…Neurological complications associated with coronavirus disease 2019 (COVID-19) infections commonly include hyposmia, headache, dizziness, encephalopathy, delirium, and cognitive slowing [1,2]. Neuropsychiatric complications associated with COVID-19 infections, including psychosis, depression, anxiety, and cognitive impairment, have been reported in older adults and to a limited extent in young adults and adolescents [3][4][5][6][7]. These complications often differ from the clinical course expected with a primary psychiatric disorder, can vary in duration of illness, have overlapping symptoms from multiple psychiatric disorders, and, therefore, do not follow well-known treatment guidelines.…”

Section: Introductionmentioning

confidence: 99%

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Progressive Neuropsychiatric Symptoms Following Recurrent COVID-19 Infections in a Previously Healthy Adolescent

Shawl,

Clark,

Edwards

et al. 2023

Case Reports in Psychiatry

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This is the almost 2-year-long course of a 16-year-old male without significant psychiatry history who abruptly developed symptoms of obsessive-compulsive disorder (OCD) and psychosis following a confirmed coronavirus disease 2019 (COVID-19) infection. His symptoms worsened following a confirmed reinfection with COVID-19. He responded poorly to treatment with selective serotonin reuptake inhibitors, antipsychotics, and benzodiazepines. This case highlights an emerging phenomenon of post-COVID-19 neuropsychiatric sequelae and presents a complicated diagnostic and treatment challenge. The differential for this patient was explored and outlined in detail, and the medical workup recommendations for new-onset mental status changes were reviewed as they pertain to the patient’s assessment and treatment course. While there are several case reports of adolescents with abrupt-onset OCD and psychosis symptoms following COVID-19 infections, none of these reports include worsening of symptoms following reinfection, and few reports follow patients beyond initial hospitalization and treatment.

show abstract

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Progressive Neuropsychiatric Symptoms Following Recurrent COVID-19 Infections in a Previously Healthy Adolescent

Shawl,

Clark,

Edwards

et al. 2023

Case Reports in Psychiatry

View full text Add to dashboard Cite

show abstract

“…Up to date, January 2023, 663 million people have been infected, and more than 6 million people have died worldwide 6 . The longterm and large-scale epidemic of SARS-CoV-2 characterized by widespread community transmission, while causing large numbers of asymptomatic, mild and long COVID cases [7][8][9] , has brought great pressure on the global public health.…”

Section: Introductionmentioning

confidence: 99%

A tissue specific-infection mouse model of SARS-CoV-2

Yang

Liu

et al. 2023

Cell Discov

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Animal models play crucial roles in the rapid development of vaccines/drugs for the prevention and therapy of COVID-19, but current models have some deficits when studying the pathogenesis of SARS-CoV-2 on some special tissues or organs. Here, we generated a human ACE2 and SARS-CoV-2 NF/F knockin mouse line that constitutively expresses human ACE2 and specifically expresses SARS-CoV-2 N gene induced by Cre-recombinase. By crossing with Cre transgenic lines allowing for lung-specific and constitutive expression, we generated lung-specific (Sftpc-hACE2-NF/F) and constitutive SARS-CoV-2 N (EIIa-hACE2-NF/F) expressing mice. Upon intranasal infection with a SARS-CoV-2 GFP/ΔN strain which can only replicate in SARS-CoV-2 N expressed cells, we demonstrated that both the Sftpc-hACE2-NF/F and EIIa-hACE2-NF/F mice support viral replication. Consistent with our design, viral replication was limited to the lung tissues in Sftpc-hACE2-NF/F mice, while the EIIa-hACE2-NF/F mice developed infections in multiple tissues. Furthermore, our model supports different SARS-CoV-2 variants infection, and it can be successfully used to evaluate the effects of therapeutic monoclonal antibodies (Ab1F11) and antiviral drugs (Molnupiravir). Finally, to test the effect of SARS-CoV-2 infection on male reproduction, we generated Sertoli cell-specific SARS-CoV-2 N expressed mice by crossing with AMH-Cre transgenic line. We found that SARS-CoV-2 GFP/ΔN strain could infect Sertoli cells, led to spermatogenic defects due to the destruction of blood-testis barrier. Overall, combining with different tissue-specific Cre transgenic lines, the human ACE2 and SARS-CoV-2 NF/F line enables us to evaluate antivirals in vivo and study the pathogenesis of SARS-CoV-2 on some special tissues or organs.

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Aripiprazole/fluoxetine

2023

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Letter to editor: Case report of long COVID-19 with psychosis in a child

Cited by 4 publications

References 5 publications

Progressive Neuropsychiatric Symptoms Following Recurrent COVID-19 Infections in a Previously Healthy Adolescent

Progressive Neuropsychiatric Symptoms Following Recurrent COVID-19 Infections in a Previously Healthy Adolescent

A tissue specific-infection mouse model of SARS-CoV-2

Aripiprazole/fluoxetine

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