“…The clinically meaningful change of cognitive function, taking MMSE as an example, depends on the baseline cognitive function of the participants. 85 A 1-point change on subjects whose baseline MMSE scores are high (i.e., [27][28][29][30] might not be considered clinically meaningful; however, for those whose MMSE scores at baseline are intermediate (i.e., 10-20), a 1-point change can be interpreted as substantial. 85 Experts consensus submitted that a 1 to 2 point change in MMSE test in a trial might be considered clinically important.…”