Letter to the editor

doi:10.1080/02656730600768589

Cited by 6 publications

(1 citation statement)

References 51 publications

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“…For hypoxia exposure, the cells were incubated in a hypoxic chamber (<1% CO 2 ) for 18 h overnight. For the induction of hyperthermia, the cells were incubated at 42 C for 2 h followed by a rescue incubation phase at 37 C for 4 h. The hyperthermia treatment regime was designed with regard to clinically relevant application protocols and transferred to a proven in vitro translational approach, reflecting well-established knowledge [17,[74][75][76][77][78][79][80][81][82][83]. Cells incubated under standard conditions in parallel served as controls.…”

Section: Cell Culture Conditions and Treatmentsmentioning

confidence: 99%

Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro

Erbes

Hirschfeld

Waldeck

et al. 2016

International Journal of Hyperthermia

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Hyperthermia-dependent down-regulatory influence on three distinct BC-related microRNAs in vitro generates translational aspects for clinical BC treatment, since the identified microRNAs miR-10b, miR-15b and miR-139 are known to have oncogenic as well as tumour suppressor functions in BC. However, an evaluation regarding the potential impact of microRNA-related hyperthermia-dependent alterations for innovative BC treatment approaches demands further analysis including in vivo data.

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Section: Cell Culture Conditions and Treatmentsmentioning

confidence: 99%

Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro

Erbes

Hirschfeld

Waldeck

et al. 2016

International Journal of Hyperthermia

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Hyperthermia with Radiotherapy and with Systemic Therapies

Zee

Rhoon

2017

Breast Cancer

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Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

et al. 2022

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Purpose of Review This review focuses on the opposing effects on the immune system of radiotherapy (RT) and the consequences for combined cancer treatment strategies of RT with immunotherapies, including hyperthermia (HT). How RT and HT might affect cancer stem cell populations is also briefly outlined in this context. Recent Findings RT is one of the crucial standard cancer therapies. Most patients with solid tumors receive RT for curative and palliative purposes in the course of their disease. RT achieves a local tumor control by inducing DNA damage which can lead to tumor cell death. In recent years, it has become evident that RT does not only have local effects, but also systemic effects which involves induction of anti-tumor immunity and possible alteration of the immunosuppressive properties of the tumor microenvironment. Though, often RT alone is not able to induce potent anti-tumor immune responses since the effects of RT on the immune system can be both immunostimulatory and immunosuppressive. Summary RT with additional therapies such as HT and immune checkpoint inhibitors (ICI) are promising approaches to induce anti-tumor immunity effectively. HT is not only a potent sensitizer for RT, but it might also improve the efficacy of RT and certain chemotherapeutic agents (CT) by additionally sensitizing resistant cancer stem cells (CSCs). Graphical abstract

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Letter to the editor

Cited by 6 publications

References 51 publications

Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro

Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro

Hyperthermia with Radiotherapy and with Systemic Therapies

Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview

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