Letter to the Editor: Autograft-derived spinal cord mass

Escada, Pedro; Capucho, Clara; Pratas-Vital, José; Arcangeli, Carlo Alberto; Lazzeri, Giovanna; Péduzzi, J.

doi:10.3171/2014.9.spine14819

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The mucinous and respiratory epithelium pathology is consistent with the hypothesis that contaminant from olfactory grafting can form an undesired mass. 5 In a critical region of the spine as in this case (the upper cervical spine), loss of function due to tumor progression can be devastating. In addition, resection is high risk.…”

Section: Discussionmentioning

confidence: 99%

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Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report

Williamson¹,

Cutler²,

Cobb³

et al. 2021

Journal of Neurosurgery: Spine

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This study describes a patient with an autograft-derived spinal cord mass following transplantation of olfactory mucosa for treatment of cervical spine injury. The authors report the case of a 35-year-old man who suffered a complete spinal cord injury (SCI) at C5–6 in 2001. The patient underwent an olfactory mucosal cell implantation at the location of injury 4 years following initial trauma. Twelve years later, the patient presented with rapidly progressive decline in upper-extremity function as well as neuropathic pain. Imaging revealed a heterogeneously enhancing intramedullary mass from C3 to C7. At surgery, the patient was found to have a posttransplant mucinous mass. Each mucinous cyst was drained and a portion of the cyst wall was removed. Histological examination demonstrated ciliated epithelium-lined fibrous tissue, submucosal glands, and mucoid material, consistent with a transplant-derived tumor. This case report both documents a rare long-term complication of olfactory mucosal cell transplantation and serves as a cautionary tale encouraging prudent use of novel treatments in a vulnerable population of patients with severe SCI.

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Section: Discussionmentioning

confidence: 99%

“…Possible explanations for tumor growth included contamination with respiratory epithelium. 5 In this paper, we present a second case of autograft-derived spinal cord tumor…”

mentioning

confidence: 99%

Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report

Williamson¹,

Cutler²,

Cobb³

et al. 2021

Journal of Neurosurgery: Spine

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Expansive Spinal Cord Injury After Autologous Olfactory Mucosal Transplantation: Case Report and Systematic Review

Bastos Siqueira Soares,

da Silva Damasceno Gomes,

Gomes Barros Maia

et al. 2024

World Neurosurgery

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Effectiveness of Activity-Based Therapy for Individuals With Spinal Cord Injury in Promoting Static and Dynamic Sitting Balance: Is Olfactory Mucosa Autograft a Factor?

Larson

2022

Topics in Spinal Cord Injury Rehabilitation

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Background Activity-based therapy (ABT) appears to improve outcomes for individuals with spinal cord injury (SCI); however, few studies have examined sitting static and dynamic balance. It was unknown whether individuals after SCI who elected to undergo an olfactory mucosa autograft (OMA) would respond differently to ABT. Objectives The first objective was to assess changes in sitting strength (static) and dynamic balance in a group of individuals with SCI undergoing intensive ABT. The second objective was to determine whether sitting balance changes would be different for those who had participated in ABT after the OMA versus those who had ABT alone. Methods A handheld dynamometer measured peak force (sitting strength) and the multi-directional reach test measured dynamic balance (n = 16). Results ABT (average dose: 7 hours per week over 4.6 months) appeared to promote improvements in sitting strength in four directions (0.6–0.8 kg per month) and dynamic balance in four of five directions (0.7–1.3 cm per month). Individuals who had undergone an OMA had similar, but not greater, improvements in static and dynamic balance when compared with those who had ABT alone. It is unknown whether balance improvements resulted from natural or other factors. Conclusion ABT may have contributed to balance changes in individuals with SCI. Although small improvements in sitting static and dynamic balance did occur, future research documenting therapy intervention details and ABT dose-response in larger groups of individuals with SCI must be performed to provide guidance as to the optimal, effective ABT dose required to generate clinically meaningful functional improvements.

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Letter to the Editor: Autograft-derived spinal cord mass

Cited by 3 publications

References 14 publications

Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report

Autograft-derived spinal cord mass in the cervical spine following transplantation with olfactory mucosa cells for traumatic spinal cord injury: case report

Expansive Spinal Cord Injury After Autologous Olfactory Mucosal Transplantation: Case Report and Systematic Review

Effectiveness of Activity-Based Therapy for Individuals With Spinal Cord Injury in Promoting Static and Dynamic Sitting Balance: Is Olfactory Mucosa Autograft a Factor?

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