Letter to the editor

Senter, Thomas P.; Kärjä, Juhani

doi:10.1002/1097-0142(19890801)64:3<781::aid-cncr2820640336>3.0.co;2-j

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Some genetic conditions have been associated with the occurrence of carcinoma in young people. KID Syndrome (keratitis, ichthyosis, and deafness) is a genetically transmitted syndrome that has been associated to malignancies in young patients [8][9][10][11]. Grob et al [9] found 28 reported cases of this syndrome and two cases of tongue carcinoma (age 6 and 7 years) in a literature review made up in 1987.…”

Section: Discussionmentioning

confidence: 99%

Head and neck squamous cell carcinoma in childhood

Carvalho

Sobrinho

Rapoport

et al. 1998

Med. Pediatr. Oncol.

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Background Squamous cell carcinoma (SCC) of the head and neck region is rare in young patients and even less frequent in children 15 years or younger children. The patients reported in the literature are isolated cases and their management is always difficult because there is no large experience or a convincing theory to support treatment decisions for every child. Procedures and Results. Four patients aged 15 years or younger were treated for SCC of head and neck between 1977 and 1995 at the Head and Neck Service of Heliópolis Hospital, São Paulo, Brazil, and with this paper we are reporting our experience with their treatment, including a genetic investigation in two cases (immunohistochemical analysis using monoclonal antibodies against p53 and c‐erbB‐2 oncogenes). These patients had no history of tobacco or ethanol abuse and no history of cancer in their families. Many authors attribute an unusual aggressiveness to SCC in childhood, with propensity to locoregional recurrence and high death rates and therefore, propose aggressive multidisciplinary therapy. Our cases, with the exception of one, had an early diagnosis and were treated using the same method we use for adults; the results were very good. Conclusions. We recommend for these cases the same protocol as for older patients. In these cases, however, the primary lesion is resected with a safety margin which is usually 2 to 3 mm larger than usual safety margins and selective neck dissection is routinely indicated. This management is adopted in an attempt to avoid postoperative irradiation which may prove to be dangerous in the future for young patients. On the other hand, we recognize that due to a small number de patients, definitive treatment recommendations cannot be made at this time. Med. Pediatr. Oncol. 31:96–99, 1998. © 1998 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Head and neck squamous cell carcinoma in childhood

Carvalho

Sobrinho

Rapoport

et al. 1998

Med. Pediatr. Oncol.

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Tumores malignos de cabeça e pescoço em pacientes com menos de 18 anos de idade

Carvalho¹,

Rapoport²,

Fava³

et al. 1998

Rev. Col. Bras. Cir.

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A conduta ideal para os pacientes menores de 18 anos portadores de tumores malignos da região de cabeça e pescoço não é uniforme nos escassos relatos de literatura. Com o objetivo de mostrar e discutir a experiência no atendimento de cinqüenta casos tratados no Serviço de Cirurgia de Cabeça e Pescoço do Complexo Hospitalar Heliópolis, no período de 1978 a 1994, os autores procederam a uma análise retrospectiva de sua casuística. Os tipos histológicos mais freqüentes foram os derivados da linhagem epitelial, 24 casos (48%) e, entre eles, o carcinoma mucoepidermóide. Entre os tumores derivados do tecido mensequimal, os mais freqüentes foram o rabdomiossarcoma e os linfomas. A cavidade oral foi o sítio mais freqüentemente acometido (15 casos, 30%). Entre todos os pacientes, apenas 21 (42%) estavam vivos e sem evidência de doença em atividade por um período que variou de seis meses a 18 anos. Quatorze (28%) pacientes morreram em decorrência de doença não controlada após um período que variou de dez dias a dois anos a contar da data do final do tratamento. De quatorze (28%) pacientes não pudemos obter informações atualizadas de suas condições e foram considerados perdidos de seguimento. Estes tumores não devem ser vistos como neoplasias de adultos localizadas em pacientes pediátricos; devem ser estudados e abordados como uma doença que apresenta características próprias e que exigem, como no adulto, que a primeira intervenção para o diagnóstico ou para o tratamento não seja intempestiva e, de fato, tenha resolubilidade.

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Letter to the editor

Cited by 2 publications

References 7 publications

Head and neck squamous cell carcinoma in childhood

Head and neck squamous cell carcinoma in childhood

Tumores malignos de cabeça e pescoço em pacientes com menos de 18 anos de idade

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