Letter to the Editor: “COVID‐19 and the endocrine system: exploring the unexplored”. Focus on acromegaly

Mercuri, Valeria; D’Amico, Tania; Gargiulo, Patrizia

doi:10.1007/s40618-020-01418-y

Cited by 7 publications

(7 citation statements)

References 3 publications

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“…Additionally, another structural biology simulation predicted octreotide as a viable repurposed drug for COVID-19 [ 149 ]. Acromegaly has been hypothesized by other studies to be a point of emphasis in COVID-19 etiology and treatment [ 150 ]. somatotropin —is a recombinant form of human growth hormone.…”

Section: Discussionmentioning

confidence: 99%

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Kartchner,

McCoy,

Dubey

et al. 2023

Biology

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Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistant hypertension to COVID-19. Cross-domain text mining of 33+ million PubMed articles within a comprehensive knowledge graph was performed using SemNet 2.0. Unsupervised rank aggregation determined which concepts were most relevant utilizing the normalized HeteSim score. A series of simulations identified concepts directly related to COVID-19 and resistant hypertension or connected via one of three renin–angiotensin–aldosterone system hub nodes (mineralocorticoid receptor, epithelial sodium channel, angiotensin I receptor). The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. Concepts were mapped to six physiological themes: altered endocrine function, 23.1%; inflammation or cytokine storm, 21.3%; lipid metabolism and atherosclerosis, 17.6%; sympathetic input to blood pressure regulation, 16.7%; altered entry of COVID-19 virus, 14.8%; and unknown, 6.5%.

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Section: Discussionmentioning

confidence: 99%

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Kartchner,

McCoy,

Dubey

et al. 2023

Biology

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“…It has been hypothesised that rapid glycometabolic and immunomodulatory control of untreated acromegaly is key to successful treatment of patients who contract COVID-19, and that somatostatin analogues are the drug of choice for treatment of respiratory failure in such patients given their potentiation of chemoreceptor response to hypoxia. 17 18 We hypothesise that it was the elevated GH, IGF-1 and the immunomodulatory effects from his untreated acromegaly that contributed to both his severe presentation and rapid recovery following initiation of octreotide. This case also underscores the importance of early multidisciplinary consultation in patients with COVID-19 and complex multisystem comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Severe respiratory failure in a patient with COVID-19 and acromegaly: rapid improvement after adding octreotide

et al. 2021

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Acromegaly is a rare disorder of unregulated hypersecretion of growth hormone that causes cardiovascular, metabolic and respiratory complications. Herein, we describe the case of a middle-aged man admitted to the hospital with severe COVID-19 found to have clinical and biochemical evidence of acromegaly. His respiratory status declined despite initiation of standard treatments, prompting initiation of subcutaneous octreotide. Following initiation of this therapy, he rapidly improved and was discharged from the hospital 2 days later. Subsequent workup revealed a pituitary macroadenoma that was surgically removed, with improvement in his acromegaly symptoms. COVID-19 disease severity is increased by pre-existing diabetes, lung disease and immunosuppression. Although this patient had obstructive sleep apnoea and pre-diabetes, we hypothesise that our patient’s acromegaly contributed to his severe course, as reflected by his rapid improvement after starting treatment with subcutaneous octreotide. Acromegaly may predispose to more severe outcomes in patients with COVID-19.

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“…Akromegali hastaları sıklıkla diyabet, kardiyovasküler hastalıklar ve obstrüktif uyku apne sendromu gibi komorbiditelere sahip olduklarından dolayı SARS-CoV-2 enfeksiyonuna karşı daha kırılgan bir yapıdadırlar (Mercuri et al, 2020). Prolaktin hormonunun immün sistemin kusursuz işlemesinde önemli bir role sahip olduğu, hatta uzun dönem hipoprolaktinemili hastaların fırsatçı enfeksiyonlar nedeniyle hayatını kaybettiği bilinmektedir.…”

Section: B Hipofiz Hastalıkları Ve Covid-19unclassified

“…birkaç durum hariç) immünolojik bir avantaj sağladığı ve özellikle kadınların fizyolojik yüksek prolaktin seviyeleri nedeniyle bu avantaja sahip olduğu bildirilmiştir. Bu mekanizmadan yola çıkarak domperidon ve metoklorpramid gibi proaktin seviyelerini yükselten dopamin antagonisti ilaçların COVID-19 hastalığından kullanımına dair çalışmalar devam etmektedir (Mercuri et al, 2020). Ancak bu hipotez dışında literatürde prolaktinomalı hastalarda COVID-19 etkisini araştıran bir çalışma henüz bulunmamaktadır.…”

Section: B Hipofiz Hastalıkları Ve Covid-19unclassified

COVID-19 ve Endokrinolojik Etkileri

İşsever¹,

Demirci²

2023

Temelden Kliniğe COVID-19

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The COVID-19 pandemic has created new and unprecedented difficulties in the follow-up and treatment of patients with endocrine disorders. For instance, patients with diabetes have a higher risk of severe disease when they are infected with SARS-CoV-2. Another example is the higher incidence of clinical presentations associated with diabetes such as insulin resistance, diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic state in patients with COVID-19. While diabetes has been showing a terrifying incidence all over the world, it was also associated with an increased mortality and morbidity risk in COVID-19 patients. This association can be stated as "the coincidence of two pandemics". Recommendations for type 2 diabetes mellitus (DM) management in the setting of this pandemic include social isolation, well hydration, tight self-glucose monitoring, and teleconference meetings. Target plasma glucose levels for inpatients with type 2 DM are 140-180 mg/dl as well as for all

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Letter to the Editor: “COVID‐19 and the endocrine system: exploring the unexplored”. Focus on acromegaly

Cited by 7 publications

References 3 publications

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Severe respiratory failure in a patient with COVID-19 and acromegaly: rapid improvement after adding octreotide

COVID-19 ve Endokrinolojik Etkileri

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