Letter to the Editor. Do bacteria contribute to formation and rupture of intracranial aneurysms?

Rabelo, Ní­collas Nunes; Rodrigues, Renan Salomão; Salame, Arthur Araújo Massoud; Braz‐Silva, Paulo Henrique; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha

doi:10.3171/2019.5.jns191267

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…Many diseases, such as rhinitis, encephalopathies, hepatitis, esophagitis, colitis, pneumonia, neonatal infections, febrile vesicles, genital infections, vasculitis, ischemic attacks, thrombosis, atherosclerosis, cancer, neuroinflammatory diseases, giant cell arthritis, and granulomatous aortitis, have all been described as secondary to these viruses. [2][3][4][5][6] Epstein-Barr virus (EBV), in particular, has been considered since 1990 to be an important pathogen in the pathophysiology of several diseases. 7 EBV, in its latent form, is present in more than 90% of the adult population, with saliva as the primary route of transmission, and is detected mainly in B lymphocytes and in the epithelium of oropharyngeal cells.…”

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confidence: 99%

“…Some risk factors are known, including female gender, age under 50 years, smoking, hyperlipidemia, aneurysm size ratio, polycystic kidney, multiple aneurysms, old cerebral infarct, family history, systemic arterial hypertension, Marfan and collagen syndromes, and Japanese and Finnish ethnicity. 1 , 2 Nevertheless, currently risk factors do not explain why some people develop IA disease, have worse disease progression, or even rupture. Some questions persist, so the main hypothesis of this study is that the presence of the virus in the brain wall might lead to more inflammatory influence in the artery.…”

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confidence: 99%

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Human herpesvirus DNA occurrence in intracranial aneurysmal wall: illustrative case

Rabelo¹,

Coelho²,

Telles³

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUND Subarachnoid hemorrhages secondary to intracranial aneurysms (IAs) are events of high mortality. These neurological vascular diseases arise from local and systemic inflammation that culminates in vessel wall changes. They may also have a possible relationship with chronic viral infections, such as human herpesvirus (HHV), and especially Epstein–Barr virus (EBV), which causes several medical conditions. This is the first description of the presence of HHV deoxyribonucleic acid (DNA) in a patient with IA. OBSERVATIONS A 61-year-old woman with a downgraded level of consciousness underwent radiological examinations that identified a 10-mm ruptured aneurysm in the anterior communicating artery. A microsurgery clip was performed to definitively treat the aneurysm and occurred without surgical complications. Molecular analysis of the material obtained revealed the presence of EBV DNA in the aneurysm wall. The patient died 21 days after admission due to clinical complications and brain swelling. LESSONS This is the first description of the presence of herpesvirus DNA in a patient with IA, presented in 2.8% of our data. These findings highlight that viral infection may contribute to the pathophysiology and is an additional risk factor for IA formation, progression, and rupture by modulating vessel wall inflammation and structural changes in chronic infections.

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confidence: 99%

mentioning

confidence: 99%

Human herpesvirus DNA occurrence in intracranial aneurysmal wall: illustrative case

Rabelo¹,

Coelho²,

Telles³

et al. 2021

Journal of Neurosurgery: Case Lessons

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“…Portanto, este estudo é inédito no tocante à análise de vírus em aneurismas, particularmente, em AIs. Há estudos que avaliam a presença do vírus em relação a outras doenças neurológicas como demências, AVCI, doença arterial aterosclerótica, como por exemplo, mas até o momento nenhum estudo foi realizado com o fim específico de estudar a presença de DNA viral na parede de AI (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) .…”

Section: Envolvimento De Microrganismos Na Formação De Aiunclassified

“…No trato gastrointestinal e a ocorrência de patologias com componentes inflamatórios, como aterosclerose, DM, fibromialgia e aneurismas (11,16) .…”

Section: Caracterizaçãounclassified

“…No caso de doença aneurismática cerebral, estudada nesta tese, as atuais evidências em relação a fatores de risco clássicos não são suficientes para justificar isoladamente as alterações inflamatórias ocorridas na microvasculatura e citoarquitetura no processo de desestruturação da parede do vaso, podendo desencadear a formação e ruptura de AI. Esta lacuna do conhecimento motivou o atual estudo a pesquisar uma relação entre infeção viral na parede vascular arterial e o AI (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) .…”

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Análise molecular de DNA viral na parede de aneurismas intracranianos rotos e não rotos

Rabelo¹

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Torque Teno virus DNA is found in the intracranial aneurysm wall—Is there a causative role?

et al. 2023

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ObjectiveTorque Teno virus (TTV) is a recently discovered virus with high prevalence worldwide, that has been associated with vascular diseases. The aim of this study is to investigate the prevalence of TTV molecular DNA in the intracranial aneurysm (IA) artery walls.MethodSamples of IA walls were collected after microsurgical clipping from 35 patients with IA (22 ruptured/13 unruptured cases). The samples were submitted to molecular DNA extraction using the EasyMag automatized extractor and performed with Qiagen DNA extraction Minikit 250. The samples underwent PCR examination with primers for β-globin as internal control using the Nanodrop® 2000 spectrophotometer. A quantitative (real-time) PCR with TTV-specific primers was performed. Clinical and radiological data of patients included was collected.ResultsTTV was detected in 15 (42.85%) cases, being 10 (45.4%) ruptured and 5 (38.4%) unruptured (p = 0.732) lesions. Multiple IAs accounted for 14 (40%) cases. Five cases (17.2%) had TTV+ and multiple aneurysms (p = 0.73). Association between presence of virus and aneurysm rupture was not statistically significant (p = 0.96).ConclusionThis study demonstrated a relatively high prevalence of viral DNA in the walls of IAs. This is the first study to identify the presence of TTV DNA in IA’s samples, which was found more often in ruptured lesions. This is an exploratory study, therefore, larger studies are required to clarify the relationships between inflammation, viral infection, IA formation and rupture.

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Letter to the Editor. Do bacteria contribute to formation and rupture of intracranial aneurysms?

Cited by 3 publications

References 5 publications

Human herpesvirus DNA occurrence in intracranial aneurysmal wall: illustrative case

Human herpesvirus DNA occurrence in intracranial aneurysmal wall: illustrative case

Análise molecular de DNA viral na parede de aneurismas intracranianos rotos e não rotos

Torque Teno virus DNA is found in the intracranial aneurysm wall—Is there a causative role?

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