“…David Sackett [34], who many consider the father of evidence-based medicine (EBM), defined EBM as integrating: (1) the best available clinical evidence from systematic research; (2) individual clinical expertise; and (3) the thoughtful identification of "individual patients' predicaments, rights, and preferences." We find ourselves in agreement with an earlier letter to CORR that states surgeon experience is important when selecting appropriate nonoperative and operative treatments [12]. Until we have prognostic evidence from large, prospective, observational studies that define key positive and negative prognostic factors for knee OA treatments, we will need to rely on surgeon experience to treat individual patients.…”