Letter to the Editor: Hemangiomas and propranolol

Strahle, Jennifer; Odden, Andrew; Maher, Cormac O.; Garton, Hugh

doi:10.3171/2013.6.peds13284

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…17,18 Ghosh and Ghosh 4 reported the use of propranolol in a 6-week-old female infant with cutaneous and intraspinal-extradural capillary hemangiomas, who exhibited an excellent response. Strahle et al 19 suggested the theoretical possibility of using propranolol to treat intracranial capillary hemangiomas based on the evident success of propranolol treatment for skin lesions and the occurrence of fewer adverse effects from propranolol treatment relative to steroid, thalidomide, bevacizumab, and temozolomide therapies. The most frequent side effects of propranolol use are low blood pressure, bradycardia, bronchospasm, and hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

A case of giant fetal intracranial capillary hemangioma cured with propranolol

Cavalheiro

Campos

Costa

2016

PED

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Fetal brain tumors are rare. This report describes a giant posterior fossa capillary hemangioma treated with 3 mg/kg/day of propranolol for 6 months. Total regression was confirmed at 1 year, and no additional tumors were observed during the subsequent 2 years. No side effects relating to the use of this drug were detected; thus, the authors believe that propranolol may be useful for treating all intracranial capillary hemangiomas.

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Section: Discussionmentioning

confidence: 99%

A case of giant fetal intracranial capillary hemangioma cured with propranolol

Cavalheiro

Campos

Costa

2016

PED

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Could propranolol be beneficial in adult cerebral cavernous malformations?

et al. 2019

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Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem CCM, multiple CCM, or those located in functional areas. Propranolol, a non-selective beta-blocker used as first-line treatment for infantile haemangiomas, has proved spectacularly effective in a few cases of adult patients with CCM. We herein review the histological, in vitro data and clinical findings that support the idea of propranolol as a potential treatment for CCM. Since one retrospective study has not been conclusive, we support the idea that prospective trials are necessary.

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Letter to the Editor: Hemangiomas and propranolol

Cited by 2 publications

References 13 publications

A case of giant fetal intracranial capillary hemangioma cured with propranolol

A case of giant fetal intracranial capillary hemangioma cured with propranolol

Could propranolol be beneficial in adult cerebral cavernous malformations?

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