Letter to the Editor: HUMAN PARVOVIRUS B19 ASSOCIATED WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

Sipahi, Tansu

doi:10.1080/08880010590935220

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…[65][66][67] Some other viruses may also cause thrombocytopenia by various mechanisms, such as Epstein-Barr virus, human herpes virus-6, parvovirus B19. [68][69][70][71][72] CMV or human herpes virus-6 in post-alloBMT patients may also cause vascular endothelial injury, which could lead to development of thrombotic microangiopathy. 73 Cytokine-induced thrombocytopenia It is possible that similar mechanisms are responsible for the thrombocytopenia in infection and cGVHD.…”

Section: Immune-mediated Thrombocytopeniamentioning

confidence: 99%

Thrombocytopenia and hemostatic disorders in chronic graft versus host disease

Pulanić

Lozier

Pavletić

2009

Bone Marrow Transplant

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Section: Immune-mediated Thrombocytopeniamentioning

confidence: 99%

Thrombocytopenia and hemostatic disorders in chronic graft versus host disease

Pulanić

Lozier

Pavletić

2009

Bone Marrow Transplant

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Cytomegalovirus-associated idiopathic thrombocytopenic purpura in Chinese children

Tang

Zou

et al. 2008

Scandinavian Journal of Infectious Diseases

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The objective was to investigate the clinical features, glycoprotein B (gB) genotype and therapy of the human cytomegalovirus (CMV)-associated idiopathic thrombocytopenic purpura (ITP) in Chinese children. Clinical features and laboratory data of 25 CMV-associated ITP, including 18 males and 7 females with a median age of 0.3 y, were analysed and compared with 116 CMV-negative ITP. The CMV gB of 17 cases was genotyped. Apart from dermatorrhagia, jaundice was noted in 6 cases. Cough, diarrhoea, fever, splenohepatomegaly, alimentary tract haemorrhage and raised ALT were also found. Compared with CMV-negative ITP, CMV-associated ITP has a younger median age, raised ALT and AST, and longer hospitalization (p<0.05, respectively). The most prevalent genotype was gB1 (15/17), followed by coinfection and gB3. Compared with congenitally CMV-infected children in our previous study, more prevalence of gB1 was noted (40/79 vs 15/17, p=0.004). Most of these cases were receiving the therapy of immunoglobulin, corticoid and/or gancyclovir with good therapeutic effect except for 2 cases. In conclusion, CMV infection, especially gB1 genotype, is an important cause of ITP and careful examination of markers of CMV in all cases of apparent 'idiopathic' ITP is required. Combination therapy of immunoglobulin, corticoid and gancyclovir is effective.

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