Letter to the Editor Re: "Silicone Allergy

Klykken, Paal C.; Curtis, James M.

doi:10.1097/mao.0b013e31815a8453

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Other possible causes of the tissue response have been hypothesized including alteration of intrinsic proteins by ethylene oxide sterilization (Pittman et al 1994, Klykkenn and Curtis 2007), immunogenicity induced by tin moeties used in catalyzing silicone adhesives (Klykken and Curtis 2007) or a foreign body reaction (Klykken and Curtis 2007). …”

Section: Discussionmentioning

confidence: 99%

Foreign Body or Hypersensitivity Granuloma of the Inner Ear After Cochlear Implantation: One Possible Cause of a Soft Failure?

Nadol

Eddington

Burgess

2008

Otology &Amp; Neurotology

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Hypothesis A tissue response in the form of foreign body or a hypersensitivity reaction to cochlear implantation is common and may be one possible cause of a soft failure of cochlear implantation. Background Following a successful cochlear implantation, delayed failure may occur. The causes of a “soft” failure, that is one in which device malfunction cannot be proven, are unknown. Methods The histopathology of the temporal bones of a patient who in life had suffered a soft failure following cochlear implantation was described. In addition, the temporal bones of 8 other subjects who in life had undergone cochlear implantation were studied for evidence of a foreign body or hypersensitivity reaction. Results In the case report, a necrotizing granulomatous giant cell reaction surrounded the cochlear implant electrode track through the mastoid, middle ear, and into the cochlea in both ears. There was osteolysis of the cribrose area, otic capsule and bone between the facial nerve and cochlea, and destruction of the organ of Corti and spiral ganglion. In the additional 8 cases studied, a similar, although less pronounced, foreign body or hypersensitivity reaction was seen in 6 (75%) of the cases. Conclusions A foreign body or hypersensitivity reaction in the form of giant cells and lymphocytic cell infiltration is common following cochlear implantation and may be one possible cause of soft failure.

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Section: Discussionmentioning

confidence: 99%

Foreign Body or Hypersensitivity Granuloma of the Inner Ear After Cochlear Implantation: One Possible Cause of a Soft Failure?

Nadol

Eddington

Burgess

2008

Otology &Amp; Neurotology

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“…Ein weiterer Mechanismus, der als mögliche seltene Ursache für eine Immunantwort auf das Implantat diskutiert wird, sind allergische Reaktionen [9]. Allerdings gilt es als äußerst umstritten, ob Silikone eine spezifische allergische Immunreaktion auslösen oder eine autoimmunähnliche Krankheit verstärken können [10]. Der Erhalt des Restgehörs im Tieftonbereich verbessert nachweislich die Sprachverständlichkeit, auch wenn das Restgehör nicht funktionell akustisch genutzt wird [11].…”

Section: Hintergrundunclassified

Cochlea-Implantation

Weiss¹

2023

Laryngorhinootologie

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Die Cochlea-Implantation ist eine unersetzbare Therapie bei Patienten mit hochgradiger Schwerhörigkeit bis Taubheit. Zugleich hinterlässt der dafür nötige Eingriff einen Schaden am Innenohr. Dieser Artikel gibt einen Überblick über die unerwünschten Auswirkungen der Cochlea-Implantation auf das Innenohr sowie über Monitoring-Methoden zur Messung der Innenohrfunktion während der Cochlea-Implantation.

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