Letter to the editor: Subcutaneous sufentanil for palliative care                 patients in a hospital setting

White, Clare; Hardy, Janet; Boyd, Alice; Hall, Tony

doi:10.1177/0269216307085177

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…White et al 38 outlined a retrospective study of 48 patients in a hospice setting who were treated with sufentanil for pain. The majority of the patients had some degree of renal impairment, although this was not made explicit.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: A European Palliative Care Research Collaborative opioid guidelines project

et al. 2011

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RECOMMENDATIONS regarding opioid use in renal impairment and cancer pain are made on the basis of pharmacokinetic data, extrapolation from non-cancer pain studies and from clinical experience. The risk of opioid use in renal impairment is stratified according to the activity of opioid metabolites, potential for accumulation and reports of successful or harmful use. Fentanyl, alfentanil and methadone are identified, with caveats, as the least likely to cause harm when used appropriately. Morphine may be associated with toxicity in patients with renal impairment. Unwanted side effects with morphine may be satisfactorily dealt with by either increasing the dosing interval or reducing the 24 hour dose or by switching to an alternative opioid.

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Section: Resultsmentioning

confidence: 99%

“…Sufentanil has been used successfully for cancer-related breakthrough pain in an intranasal preparation and in palliative care as a CSCI. 38,216 The majority of the patients receiving sufentanil as a CSCI had some degree of renal impairment, although the level was not specified. 38…”

Section: Pharmacokinetics Of Opioidsmentioning

confidence: 99%

A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: A European Palliative Care Research Collaborative opioid guidelines project

et al. 2011

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“…Sufentanyl is often used as a replacement to fentanyl when the volume of fentanyl needed for treatment is above the range which can be administered through an injection [33,34,35]. Sufentanyl is more effective at a lower dose for pain control among patients [33].…”

Section: Pain Medication Opioid Analgesics and Non-steroidal Antimentioning

confidence: 99%

“…Sufentanyl is more effective at a lower dose for pain control among patients [33]. It is mostly used for the treatment of patients with renal impairment [34].…”

Section: Pain Medication Opioid Analgesics and Non-steroidal Antimentioning

confidence: 99%

Molecular Basis of Cancer Pain Management: An Updated Review

2019

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Pain can have a significantly negative impact on the quality of life of patients. Therefore, patients may resort to analgesics to relieve the pain. The struggle to manage pain in cancer patients effectively and safely has long been an issue in medicine. Analgesics are the mainstay treatment for pain management as they act through various methods on the peripheral and central pain pathways. However, the variability in the patient genotypes may influence a drug response and adverse drug effects that follow through. This review summarizes the observed effects of analgesics on UDP-glucuronosyl (UGT) 2B7 isoenzyme, cytochrome P450 (CYP) 2D6, μ-opioid receptor μ 1 (OPRM1), efflux transporter P-glycoprotein (P-gp) and ATP-binding cassette B1 ABCB1/multiple drug resistance 1 (MDR1) polymorphisms on the mechanism of action of these drugs in managing pain in cancer. Furthermore, this review article also discusses the responses and adverse effects caused by analgesic drugs in cancer pain management, due to the inter-individual variability in their genomes.

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“…Hydromorphone is a good alternative to morphine when higher doses are required (or when morphine metabolites become problematic) because it is more potent, allowing for lower infusion rates required by SC infusion [38,39]. Fentanyl, sufentanil, and alfentanil have also been delivered via this route [37,[40][41][42][43][44] but are more expensive options.…”

Section: Subcutaneous (Sc)mentioning

confidence: 99%

Alternative Routes to Oral Opioid Administration in Palliative Care: A Review and Clinical Summary

et al. 2014

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Letter to the editor: Subcutaneous sufentanil for palliative care patients in a hospital setting

Cited by 12 publications

References 7 publications

A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: A European Palliative Care Research Collaborative opioid guidelines project

A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: A European Palliative Care Research Collaborative opioid guidelines project

Molecular Basis of Cancer Pain Management: An Updated Review

Alternative Routes to Oral Opioid Administration in Palliative Care: A Review and Clinical Summary

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