Letter to the EditorCytomegalovirus infection in central european vitiligo patients?

Pichler, Robert; Sfetsos, Konstantin; Auböck, Josef; Badics, Birgit; Gutenbrunner, Sabrina; Berg, Jörg

doi:10.1080/08916930500050368

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…For further evaluation of involvement of cellular immunity in vitiligo disease, we analyzed blood cell count and lymphocyte subfractions by flow cytometry in peripheral blood. Data of CMV infection parameters [5] and endocrine evaluation including melanotropins [6] in the same patient cohort have been presented elsewhere.…”

Section: Patientsmentioning

confidence: 99%

Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio

Pichler

Sfetsos

Badics

et al. 2009

Wien Med Wochenschr

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Vitiligo is a disorder of pigmentation associated with an autoimmune-mediated loss of melanocytes from the epidermis. Humoral immunity and the involvement of cellular immunity have been investigated in the pathogenesis of vitiligo. We evaluated the role of pro-inflammatory cytokines and lymphocyte fractions in peripheral blood in a cohort of Austrian patients with vitiligo. Morning blood samples from 40 patients with vitiligo were collected. Twenty-one patients had active and 19 had stable vitiligo disease. All patients were suffering from non-segmental vitiligo at different stages of the disease. Sixteen persons presented with an additional autoimmune thyroid disease. To evaluate a possible involvement of proinflammatory cytokines in vitiligo we measured sTNF-RI (soluble tumour necrosis factor receptor I), IL-6 and additionally CIC (circulating immune complexes). We compared these findings to the data from matched normal persons. To investigate the mechanisms of cellular immunity, peripheral blood cell count and lymphocyte subtype analysis by flow cytometry were done. sTNF-RI, IL-6 and CIC serum levels were in the normal range. In the patient group median sTNF-RI level was 1.5 ng/ml and median CIC level was 35.2 microg/ml, and no statistically significant differences to the control group were observed. Median IL-6 level in vitiligo patients was 2.7 pg/ml and in the normal range-but higher than the median level of 0.5 pg/ml observed in normal persons (p < 0.001). Absolute and relative counts of lymphocyte subtypes were normal. The ratio of CD4+/CD8+ T-cells had an elevated median value of 2.6 [quartiles 2.0; 3.1]. 61% of the vitiligo patients had a ratio higher than 2.4, which was the normal cut-off point. In most vitiligo patients the balance of cytotoxic/suppressor and helper/inducer T-cells in peripheral blood is disturbed which might lead to a predominance of T-cell subtypes in the intracutaneous site of autoimmune melanocyte loss.

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Section: Patientsmentioning

confidence: 99%

Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio

Pichler

Sfetsos

Badics

et al. 2009

Wien Med Wochenschr

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“…Viral infection, autoimmunity and increased activation of superoxide radicals are also considered in the aetiopathogenesis 1,2 . Melanocyte damage in vitiligo, which is stimulated by viruses such as HIV, HCV and Epstein‐Barr virus, has been also mentioned by some authors 3–6 …”

Section: Introductionmentioning

confidence: 97%

“…1,2 Melanocyte damage in vitiligo, which is stimulated by viruses such as HIV, HCV and Epstein-Barr virus, has been also mentioned by some authors. [3][4][5][6] Toll-like receptors (TLRs) are pattern recognition transmembrane receptors. They recognize some conserved components of endogenous molecules such as heat-shock proteins, apoptotic cells, increased oxidative stress and exogenous molecules such as bacteria or virus.…”

Section: Introductionmentioning

confidence: 99%

TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients

Karaca

Öztürk

Gerceker

et al. 2012

Acad Dermatol Venereol

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“…Additionally, similarities with other ADs like the chronic relapse and remission, circulating anti-melanocyte antibodies, and response to immunosuppressive treatments were observed for vitiligo (Farrokhi et al, 2005;Glassman, 2011). Moreover, the periphery of vitiligo lesions shows sparse infiltration of CD8 + T cells, a key characteristic of autoimmune disorder (Pichler et al, 2009;YAGHOOBI et al, 2011). Additionally, a sharp increase in the ratio of T H to T C cells was observed in vitiligo patients; however, the B cell role was not observed directly in tissues.…”

Section: Vitiligomentioning

confidence: 83%

Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity

Banerjee

Nara

Chakraborty

et al. 2022

Front. Cell Dev. Biol.

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The pathophysiology of autoimmune disorders is multifactorial, where immune cell migration, adhesion, and lymphocyte activation play crucial roles in its progression. These immune processes are majorly regulated by adhesion molecules at cell–extracellular matrix (ECM) and cell–cell junctions. Integrin, a transmembrane focal adhesion protein, plays an indispensable role in these immune cell mechanisms. Notably, integrin is regulated by mechanical force and exhibit bidirectional force transmission from both the ECM and cytosol, regulating the immune processes. Recently, integrin mechanosensitivity has been reported in different immune cell processes; however, the underlying mechanics of these integrin-mediated mechanical processes in autoimmunity still remains elusive. In this review, we have discussed how integrin-mediated mechanotransduction could be a linchpin factor in the causation and progression of autoimmune disorders. We have provided an insight into how tissue stiffness exhibits a positive correlation with the autoimmune diseases’ prevalence. This provides a plausible connection between mechanical load and autoimmunity. Overall, gaining insight into the role of mechanical force in diverse immune cell processes and their dysregulation during autoimmune disorders will open a new horizon to understand this physiological anomaly.

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Letter to the EditorCytomegalovirus infection in central european vitiligo patients?

Cited by 7 publications

References 7 publications

Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio

Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio

TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients

Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity

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