Letter. Upper airway obstruction in an HIV-1 infected child with acute Epstein-Barr virus infection

Weber, H. Christian; R, Gie; Mf, Cotton; Annandale, C.H.; Kling, Stephen J.; Loock, Kim Vande

doi:10.1093/tropej/45.2.119

Journal of Tropical Pediatrics

1999

DOI: 10.1093/tropej/45.2.119

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Letter. Upper airway obstruction in an HIV-1 infected child with acute Epstein-Barr virus infection

H. Christian Weber¹,

Gie R²,

Cotton Mf³

et al.

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Cited by 2 publications

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Monotherapy in an era of combination therapy: is there a benefit? Experience in HIV-1-infected symptomatic South African children

Pijnenburg

Cotton

2000

Annals of Tropical Paediatrics

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We investigated the benefit of treating HIV-1-infected children with monotherapy where resources are limited. A retrospective chart review was undertaken in 12 symptomatic HIV-1-infected children treated with zidovudine or didanosine for at least 2 months. The main outcome measure was the effect on hospitalization. Anti-retroviral therapy was commenced in nine children because of prolonged or frequent hospitalization. Of three whose primary indication was bleeding secondary to thrombocytopenia, two had been hospitalized owing to severe intercurrent illness. One child had failure to thrive and another encephalopathy. Monotherapy was considered beneficial in all cases. Median duration of follow-up was 6.5 (2-31) months. The hospitalization index (days in hospital before and after start of monotherapy, divided by the total number of days before and after start of monotherapy) decreased from a median of 0.115 prior to therapy to 0.037 on therapy (p = 0.045, Wilcoxon matched pairs test). This study presents observational data supporting the investigation of monotherapy in resource-poor countries. It was associated with a significant reduction in hospitalization and appeared to result in clinical improvement. Prolonged or frequent hospitalization might represent a novel indication for use because in our setting the cost of hospitalization could potentially provide a 12-month-old infant with monotherapy for 2 months.

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Monotherapy in an era of combination therapy: is there a benefit? Experience in HIV-1-infected symptomatic South African children

Pijnenburg

Cotton

2000

Annals of Tropical Paediatrics

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The impact of human immunodeficency virus 1 on largyngeal airway obstruction in children

Jeena

Bobat²,

Kindra³

et al. 2002

Archives of Disease in Childhood

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Letter. Upper airway obstruction in an HIV-1 infected child with acute Epstein-Barr virus infection

Cited by 2 publications

References 5 publications

Monotherapy in an era of combination therapy: is there a benefit? Experience in HIV-1-infected symptomatic South African children

Monotherapy in an era of combination therapy: is there a benefit? Experience in HIV-1-infected symptomatic South African children

The impact of human immunodeficency virus 1 on largyngeal airway obstruction in children

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