Letters to the Editor

Gd, Peddle; Mm, Sleeper; Mj, Ryan; Kittleson,; Pion, Paul D.

doi:10.2460/javma.234.12.1525

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Whyte et al [ 27 ] found a significant positive correlation between ALT and PD and a negative correlation between platelet count and PD. In addition to renal, hepatic and systemic inflammation, it has been suggested that PD may be associated [ 28 , 29 ] with increased risk for cardiovascular problems such as endocarditis and cardiomyopathy. For example, Glickman et al [ 28 ] reported that dogs with PD had a higher frequency of cardiovascular-related events and that the frequency increased with increasing severity of PD.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Glickman et al [ 28 ] reported that dogs with PD had a higher frequency of cardiovascular-related events and that the frequency increased with increasing severity of PD. Others have questioned the validity of these results indicating more research is needed before definitive conclusions can be drawn [ 29 ]. These studies suggest that any degree of PD increases risk for several systemic diseases and merits concern.…”

Section: Discussionmentioning

confidence: 99%

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A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois

2018

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The objectives of this cross-sectional study were: 1) to estimate the prevalence and characterize the severity of periodontal disease in a population of dogs housed in commercial breeding facilities; 2) to characterize PD preventive care utilized by facility owners; and 3) to assess inter-rater reliability of a visual scoring assessment tool. Adult dogs (N = 445) representing 42 breeds at 24 CB facilities in Indiana and Illinois were assessed. Periodontal disease was scored visually using the American Veterinary Dental Collage 0-IV scale. Inter-rater reliability was assessed on 198 dogs and facility owners were asked to provide information about the preventive care utilized. The overall prevalence of periodontal disease (Grades I-IV) was 86.3% (95% CI: 82.9, 89.3). An ordered logistic regression analysis found age (OR = 1.4; 95% CI 1.24, 1.54; P<0.0001), facility (OR = 1.13; 95% CI 1.09, 1.18; P<0.0001), sex (OR = 1.7; 95% CI 1.12, 2.65; P = 0.013), and non-professional dental scaling (OR = 2.82; 95% CI 1.34, 5.91; P = 0.006) to be statistically significant. Inter-rater reliability analysis found agreement to be 86.2%, with a weighted kappa of 0.4731 (95% CI 0.3847, 0.5615) indicating moderate agreement. Risk of periodontal disease increased with increasing age. Additionally, a trend toward decreasing risk with increasing weight was also found, although it was not statistically significant. The trends identified agree with studies that have evaluated periodontal disease in the companion dog population and do not support the assumption that the dental health of dogs in commercial breeding facilities is worse than that of the population as a whole. Although there were few cases of severe periodontal disease and all facilities employed some type of preventive care in this sample, the large number of dogs with some degree of disease (Grades I-IV) suggests that further investigation of preventive care is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois

2018

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Periodontal disease and coronary heart disease

2006

Br Dent J

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Identical mitochondrial somatic mutations unique to chronic periodontitis and coronary artery disease

Pallavi

Chandra

Reddy

et al. 2016

J Indian Soc Periodontol

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Context:The inflammatory processes involved in chronic periodontitis and coronary artery diseases (CADs) are similar and produce reactive oxygen species that may result in similar somatic mutations in mitochondrial deoxyribonucleic acid (mtDNA).Aims:The aims of the present study were to identify somatic mtDNA mutations in periodontal and cardiac tissues from subjects undergoing coronary artery bypass surgery and determine what fraction was identical and unique to these tissues.Settings and Design:The study population consisted of 30 chronic periodontitis subjects who underwent coronary artery surgery after an angiogram had indicated CAD.Materials and Methods:Gingival tissue samples were taken from the site with deepest probing depth; coronary artery tissue samples were taken during the coronary artery bypass grafting procedures, and blood samples were drawn during this surgical procedure. These samples were stored under aseptic conditions and later transported for mtDNA analysis.Statistical Analysis Used:Complete mtDNA sequences were obtained and aligned with the revised Cambridge reference sequence (NC_012920) using sequence analysis and auto assembler tools.Results:Among the complete mtDNA sequences, a total of 162 variations were spread across the whole mitochondrial genome and present only in the coronary artery and the gingival tissue samples but not in the blood samples. Among the 162 variations, 12 were novel and four of the 12 novel variations were found in mitochondrial NADH dehydrogenase subunit 5 complex I gene (33.3%).Conclusions:Analysis of mtDNA mutations indicated 162 variants unique to periodontitis and CAD. Of these, 12 were novel and may have resulted from destructive oxidative forces common to these two diseases.

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Letters to the Editor

Abstract: label instructs, the calcium-to-phosphorus ratio becomes substantially inverted. In addition, vitamin D, another nutrient whose deficiency contributed to the disease in our puppy, was not and still does not appear to be supplemented in the premix.

Cited by 3 publications

References 7 publications

A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois

A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois

Periodontal disease and coronary heart disease

Identical mitochondrial somatic mutations unique to chronic periodontitis and coronary artery disease

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