Letters to the Editor

Chiara, Luca Di; L, Christos; Witold, T; Iacoviello, Massimo; M, Antonella; B, Marzia De; Agostino, Silvia V.

doi:10.1002/clc.21952

Clinical Cardiology

2012

DOI: 10.1002/clc.21952

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Letters to the Editor

Luca Di Chiara¹,

Christos L²,

T Witold³

et al.

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Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

Pessôa

Bressan

Freude³

2019

WJSC

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Up until the mid 2000s, the capacity to generate every cell of an organism was exclusive to embryonic stem cells. In 2006, researchers Takahashi and Yamanaka developed an alternative method of generating embryonic-like stem cells from adult cells, which they coined induced pluripotent stem cells (iPSCs). Such iPSCs possess most of the advantages of embryonic stem cells without the ethical stigma associated with derivation of the latter. The possibility of generating “custom-made” pluripotent cells, ideal for patient-specific disease models, alongside their possible applications in regenerative medicine and reproduction, has drawn a lot of attention to the field with numbers of iPSC studies published growing exponentially. IPSCs have now been generated for a wide variety of species, including but not limited to, mouse, human, primate, wild felines, bovines, equines, birds and rodents, some of which still lack well-established embryonic stem cell lines. The paucity of robust characterization of some of these iPSC lines as well as the residual expression of transgenes involved in the reprogramming process still hampers the use of such cells in species preservation or medical research, underscoring the requirement for further investigations. Here, we provide an extensive overview of iPSC generated from a broad range of animal species including their potential applications and limitations.

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Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

Pessôa

Bressan

Freude³

2019

WJSC

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Letters to the Editor

Cited by 1 publication

References 16 publications

Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

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