Leucas aspera Nanomedicine Shows Superior Toxicity and Cell Migration Retarded in Prostate Cancer Cells

Mohan, Anjusha; Nair, Shantikumar V.

doi:10.1007/s12010-016-2291-5

Cited by 14 publications

(16 citation statements)

References 22 publications

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“…A Leucas aspera nanoformulation showed a concentration- and time-dependent in vitro cytotoxicity on PC-3 cells that was confirmed by the in vitro hemolysis assay, cellular uptake studies, cell aggregation studies, and cell migration assays [179]. Moringa oleiferna inhibited the cell proliferation of PC-3 cell lines in a concentration-dependent manner (IC 50 = 14.3 and 22.2 μg/mL) [110].…”

Section: Plant Extracts and Plant-derived Bioactives In Prostate Cmentioning

confidence: 99%

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

et al. 2019

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Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.

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Section: Plant Extracts and Plant-derived Bioactives In Prostate Cmentioning

confidence: 99%

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

et al. 2019

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“…NPs of BS were prepared by nanoprecipitation method [33][34][35][36][37][38][39][40]. Primarily, the BS extract ∼25 mg was dissolved in 1 ml methanol using a rotary mixer.…”

Section: Synthesis Of Bs Npsmentioning

confidence: 99%

“…Each experiment was performed in duplicates at each concentration. The percentage of haemolysis by the extracts was calculated using the following formula [40]:…”

Section: Haemolysis Assaymentioning

confidence: 99%

“…In our paper, BS medicinal plant was selected based on the antitumour [41] activity and flavonoids such as luteolin 7-methyl ether, isoorientin, bitflavones, 4-and 5-caffeoylquinic acid [42]. BS plant was dried and extracted via solvent technique [38] and BS nanoscale production were achieved by nanoprecipitation techniques [33][34][35][36][37][38][39][40].…”

Section: Bs Crude Extract and Nanomedicinementioning

confidence: 99%

“…Collectively, recent updates on green nanomedicine have been documented in an area of prostate cancer specific theragnosis [32]. In contrast, our group developed a simple, non‐toxic, and efficient phytoactive nanomedicines such as boswellic acid in vitro [33], in vivo [34], Phyllanthus niruri [35], Tinospora cardifolia [36], silymarin [37], Baliospermum montanum [38], Plumbago zeylanica [39], and Leucas aspera [40] have been demonstrated as a therapeutic potential of those nanomedicines agent for prostate cancer. In the search of extended novel natural products for their efficacy against prostate cancer, we investigated Biophytum sensitivum (BS) is a medicinal plant traditionally used to cure various diseases.…”

Section: Introductionmentioning

confidence: 99%

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Biophytum sensitivum nanomedicine reduces cell viability and nitrite production in prostate cancer cells

Raju

Nair

2017

IET nanobiotechnol.

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Phytomedicine research received tremendous attention for novel therapeutic agent due to their safety and low cost. We assessed a novel nanoformulation of Biophytum sensitivum (BS), natural flavonoids for their improved efficacy and superior bioavailability against crude extract for prostate cancer cells (PC3). We prepared a nanomedicine of BS by nanoprecipitation method and size analysis via DLS and SEM revealed a range of 100-118 nm and surface zeta potential as −9.77 mV. FTIR was performed to evaluate functional for presence of carbonyl and aromatic rings, respectively. Human PC3 cells showed concentration at 0.5, 0.8, and 1 mg/ml dependent cytotoxicity 22, 39, and 56% for 24 h, whereas 43, 41, and 67% for 48 h of BS nanomedicine compared with crude 11, 22, and 53% for 24 h and 38, 31, and 60% for 48 h, respectively. Haemocompatibility of BS nanomedicine at the concentration of 0.5, 0.8, and 1 mg/ml did not show blood aggregation. Cellular uptake was confirmed using rhodamine-conjugated BS nanomedicine for 48 h. Interestingly, BS nanomedicine 1 mg/ml decreases the nitrite productions in PC3 cells. Collectively, BS nanomedicine has the potential anti-cancer agents with biocompatible and enhanced efficacy can be beneficial for the treatment of prostate cancer

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Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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Because of the increasing demand for natural products, the development of nanoformulations containing natural active ingredients requires in‐depth knowledge of the substances used, methods of obtaining, and stability profiles to ensure product quality, efficacy, and safety. Considering this, the bibliography of the last five years presented in databases (PubMed and Science Direct) was discussed in this work, discussing the study with medicinal plants to obtain active metabolites with therapeutic properties, as well as the different nano‐systems responsible for carrying these molecules. Due to the wealth of biodiversity found in the world, many species are submitted to the extraction process for several purposes. However, identifying, classifying, and quantifying the constituents of herbal matrices are crucial steps to verify their therapeutic potential. In addition, knowing the techniques of production and elaboration of nanotechnology products allows the optimization of the incorporation of herbal extracts as an innovation target. For studies to be successful, it is necessary to exhaust experimental results that guarantee the efficacy, safety, and quality of natural nanosystems, with the objective of obtaining reliable answers in nanotechnology therapy.

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Leucas aspera Nanomedicine Shows Superior Toxicity and Cell Migration Retarded in Prostate Cancer Cells

Cited by 14 publications

References 22 publications

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

Biophytum sensitivum nanomedicine reduces cell viability and nitrite production in prostate cancer cells

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

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