Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

Abstract

!A phytochemical investigation of the acetone extract from the aerial parts of Leucas mollissima afforded one new (−)epi-marmelo lactone, (2 S, 4R, 6 S)-2,6-dimethyl-6 hydroxy-7-ene-4-olide (1), along with five known compounds, schensianol A (2), vanillin (3), β-hydroxy propiovanillone (4), lanost-9(11),25-diene-3β,24β-diol (5), and lanost-9(11),23E(24)-diene-3β,25-diol (6). Similarly, an investigation of the methanol extract of the aerial parts of L. mollissima resulted in the isolation of three known compounds, (+)-syringaresinol (7), anisofolin A (8), and apigenin 7-O-β-D(− 6′′-p-E-coumaroyl)-glucoside (9). Structure elucidation of the isolated compounds was carried out using detailed analysis of 1D and 2D nuclear magnetic resonance. All compounds were evaluated for antimalarial activity against Plasmodium falciparum (3D7) and for antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis. Compound 8 was found to have promising antimalarial activity (IC 50 4.39 ± 0.25 µM), promising antimycobacterium activity [IC 50 4.50 ± 0.75 µM (3.31 µg/mL)] against M. tuberculosis H37Ra and at 100 µg/mL, showed 55.6 % inhibition of M. bovis. Compound 9 showed moderate inhibition of P. falciparum growth (35% inhibition at 10 µM) with respect to the positive control atovaquone and 67.4 % inhibition against M. bovis at 100 µg/mL with respect to the positive control rifampicin.

A New Dinor-cis-Labdane Diterpene and Flavonoids with Antimycobacterium Activity from Colebrookea oppositifolia

“…ex Benth. (Lamiaceae) by Chinchansure and coworkers, with its antimycobacterium activity, is also reported in this study [21].…”

“…Despite the availability of treatment, tuberculosis (TB) continues to be a deadly disease [16][17][18]. We are continuously involved in the process of the isolation of novel phytochemicals with promising anti-TB activity [19][20][21]. During our program for the isolation of anti-TB compounds from plants found in Western Ghats of Maharashtra, India, a phytochemical analysis of the acetone extract of the aerial parts of C. oppositifolia was performed.…”

Antiviral potential of phytoligands against chymotrypsin-like protease of COVID‐19 virus using molecular docking studies: An optimistic approach

“…Cordifolin which is an oxygenated chalcone exhibited inhibition of HIV protease 37 . Anisofolin A exclusively reported in the owers of Leucas species found to have promising anti-mycobacterium activity against M. tuberculosis H37Ra, antimalarial activity against Plasmodium falciparum (3D7) 38 . The owers are given in the form of syrup or with honey as a domestic remedy for bronchial asthma, colds, cough 39 .…”