Leucémie aiguë néonatale et Blueberry Muffin syndrome : à propos d’un cas spontanément régressif

Leukemia Cutis in Childhood Acute Myeloid Leukemia: Epidemiological, Clinical, Biological, and Prognostic Characteristics of Patients Included in the ELAM02 Study

“…2,5 Congenital forms of LC may present as blueberry muffin syndrome and can regress spontaneously before any blasts appear in blood. 5…”

“…Several case reports as well as previous series including both adult and pediatric patients have suggested such an association. 3,5,6 Age could be a confounding factor since FAB type M5 is more common in very young children. 1,7…”

“…Even though we found only 1 patient with a congenital form of AML with LC, most of clinical case reports of childhood AML with LC concern infants and neonates suggesting LC is more frequent in very young children. 2,5 Congenital forms of LC may present as blueberry muffin syndrome and can regress spontaneously before any blasts appear in blood. 5 More than 60% of patients with LC had FAB type M5.…”

“…Several case reports as well as previous series including both adult and pediatric patients have suggested such an association. 3,5,6 Age could be a confounding factor since FAB type M5 is more common in very young children. 1,7 MLL-rearrangement was the most frequent finding in patients with LC, observed in nearly half of these patients.…”

Congenital Perianal and Abdominal Nodules

“…The presence of red‐bluish nodules from birth (blueberry muffin baby and its mimics) poses a differential diagnosis including neonatal hemolysis (4), congenital infections such as rubella, cytomegalovirus, or toxoplasma, and tumor processes such as Langerhans cell histiocytosis, neuroblastoma, and rhabdomyosarcoma (4–7). The exclusion of the first two conditions is fundamentally established from the clinical history, complete blood count, and serological findings, while differentiation from tumor processes is established by the histopathological study.…”