Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23

Kim, Hyun A; Park, Woo‐Jae; Jeong, Hakyung; Lee, Hyun-e; Lee, Jun Young; Kwon, Nyoun Soo; Baek, Kwang Jin; Kim, Dong-Seok; Yun, Hye‐Young

doi:10.1016/j.bbalip.2012.02.010

Cited by 27 publications

(73 citation statements)

References 36 publications

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“…We found that LGI3 was expressed in adipose tissues and was downregulated during adipocyte differentiation and upregulated in adipose tissues of ob/ob mice and high fat diet (HFD)-fed mice [4,8]. We reported that LGI3 suppressed adipogenesis through its receptor, a disintegrin and metalloproteinase domain-containing protein 23 (ADAM23) and that LGI3 increased pro-inflammatory proteins including TNF-a in macrophage cells [4].…”

Section: Introductionmentioning

confidence: 95%

“…We proposed that LGI3 may be a pro-inflammatory adipokine that interplays with other adipokines in adipogenesis and metabolic inflammation [4]. In this study, we present the evidences that LGI3 and TNF-a upregulate each other through a key inflammatory transcription factor, NF-jB.…”

Section: Introductionmentioning

confidence: 95%

“…We previously showed that LGI3 played regulatory roles in neuronal exocytosis and differentiation [2,3]. Besides the nervous system, LGI3 is expressed in diverse tissues including skin and adipose tissues [4,5]. We reported that ultraviolet B-irradiation-induced secretion of LGI3 promoted survival of human keratinocytes [5].…”

Section: Introductionmentioning

confidence: 96%

“…We reported that LGI3 suppressed adipogenesis through its receptor, a disintegrin and metalloproteinase domain-containing protein 23 (ADAM23) and that LGI3 increased pro-inflammatory proteins including TNF-a in macrophage cells [4].…”

Section: Introductionmentioning

confidence: 99%

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Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB

et al. 2015

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“…LGI3 was also detected in aged monkey brains and was determined to be involved in amyloid peptide uptake by astrocytes (4). Outside of the brain, we have found that LGI3 is also expressed in adipose tissues and 3T3-L1 pre-adipocytes and regulates adipogenesis as a candidate adipokine (5). Recently, we reported that LGI3 is highly expressed in human skin and secreted from UVB-irradiated epidermal keratinocytes (6,7).…”

Section: Introductionmentioning

confidence: 95%

Leucine‐rich glioma inactivated 3 is a melanogenic cytokine in human skin

Jeong

Kim

et al. 2014

Experimental Dermatology

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aging (14). It was important to distinguish previously described increase in EOTAXIN in the advanced CTCL patients (17) from normal aging. We found EOTAXIN and MIP-1B to be significantly higher across all age groups in patients with MF/SzS, suggestive of their relevance to the disease pathogenesis (Fig. S1).In conclusion, we demonstrate for the first time that the immune profiles of MF/SzS cluster closer to HIV and then to normal controls and demonstrate unique, cancer-specific and age-related immunological changes. It underscores an immunological dysbalance and immune-compromised state of patients with MF/SzS. AcknowledgementsWe thank Sue McCann, MRN for technical support with blood collection. This work was supported by SPORE NIH 5P50CA121973-03, Project 5 (to LJG) and UL1 RR024153 from the National Center for Research Resources (NCRR). Author contributionsLG and OA designed the study, analysed the data and wrote the paper. AL performed the Luminex assay. YL performed the statistical analysis. AL participated in the design of the work and the critical review of the paper. Conflict of interestThe authors state no conflict of interest. Supporting InformationAdditional Supporting Information may be found in the online version of this article: Figure S1. Age dependent biomarker expression in patient with MF/SzS and age matched controls. Table S1. Comparative analysis of soluble proteins. Medicine, Korea, Abstract: Recently, we demonstrated that leucine-rich glioma inactivated 3 (LGI3) is expressed in human skin. However, the effects of LGI3 on melanocytes remain unknown. The present study demonstrated that LGI3 can serve to stimulate melanogenesis without affecting cell viability. To determine the effects of LGI3 on melanin synthesis, normal human melanocytes and Mel-Ab cells were treated with recombinant LGI3 and melanin content was measured. Our results showed that LGI3 promoted melanin synthesis in both cell types. Moreover, upregulation of microphthalmia-associated transcription factor (MITF) and tyrosinase was observed at both the mRNA and protein levels via RT-PCR and Western blotting, respectively. Furthermore, immunohistochemical staining showed that the expression of LGI3 increased in the basal layer of melasma skin samples, whereas it decreased slightly in vitiligo samples. These results suggest that LGI3 may play a role as a melanogenic cytokine in human skin.

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