Leucocytoclastic vasculitis, hepatitis C virus-associated mixed cryoglobulinaemia with biclonal gammopathy and Waldenstrom macroglobulinaemia

Álvarez-Ruiz, Sara; García-Río, I; Aragüés, Maximiliano; Fraga, José Carlos Soares de; Pueyo, J Locertales; Fernández‐Herrera, Jesús; García‐Diez, Amaro

doi:10.1111/j.1365-2133.2004.06207.x

Cited by 6 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ing case reports describing IFNα and ribavirin treatment of HCV-associated cryoglobulinemia and WM, although to the best of our knowledge none of them using an IFNfree therapy. 8,12,18 In this report, we have described the case of a patient with HCV-related cirrhosis with associated cryoglobulinemia and WM, and who was treated with multiple rituximab cycles. While anti-CD20 treatment minimally modified the course of the disease, and IFN-based antiviral treatment with HCV was difficult to tolerate and unsuccessful, HCV eradication with IFN-free treatment led to a dramatic clinical and biochemical improvement in her haematological condition, besides ameliorating liver function as well as liver stiffness.…”

Section: Discussionmentioning

confidence: 99%

Improvement in Waldenström’s Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals

Crespi

Demarzo

Brunacci

et al. 2018

Annals of Hepatology

View full text Add to dashboard Cite

Chronic hepatitis C (HCV) virus infection may be associated with several non-hepatic manifestations, mainly driven by chronic immune stimulation, such as mixed cryoglobulinemia and Non-Hodgkin’s Lymphoma. This association has been proved by several meta-analyses and some interventional studies demonstrating that antiviral treatment may be effective in inducing HCV-associated lymphoma regression. The recent advent of direct acting antivirals (DAAs) in the therapeutic armamentarium of HCV infection made possible treatment of patients with advanced liver disease. Here we report on a rare association of a cirrhotic patient with HCV and Waldenström’s Macroglobulinemia with severe cryoglobulinemia, who had already failed an interferon-based antiviral regimen, whose haematologic disease was ameliorated by HCV eradication following treatment with sofosbuvir and simeprevir with ribavirin, and where successful treatment was accompanied also by consistent improvement in liver function and parameters of portal hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement in Waldenström’s Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals

Crespi

Demarzo

Brunacci

et al. 2018

Annals of Hepatology

View full text Add to dashboard Cite

show abstract

“…Treatment with IFN-alpha and ribavirin was reported in a patient with HCV-associated cryoglobulinemia and WM [17]. After 9 months of antiviral therapy, the patient's HCV titers became undetectable, and bone marrow biopsy revealed regression of lymphoid infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…After 9 months of antiviral therapy, the patient's HCV titers became undetectable, and bone marrow biopsy revealed regression of lymphoid infiltration. Eventually, a liver transplant was performed and the patient remained asymptomatic [17]. Another case report of comorbid HCV and WM described a combined cytotoxic and antiviral strategy with cyclophosphamide, prednisone, pegylated IFN, and alpha-2b treatments.…”

Section: Discussionmentioning

confidence: 99%

Waldenström Macroglobulinemia in Hepatitis C: Case Report and Review of the Current Literature

Nipp

Mitchell

Pishko

et al. 2014

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

Background. Recent literature has associated hepatitis C virus with the development of non-Hodgkin lymphoma. Hepatitis C virus infection appears to promote lymphoproliferation, providing a plausible mechanism for a causative association; however, despite prior reports of patients with comorbid hepatitis C infection and Waldenström macroglobulinemia, the literature is in disagreement regarding whether there exists an association between these two conditions. Case Presentation. This case report describes a 57-year-old African-American male with chronic hepatitis C infection and cryoglobulinemia who presented with several episodes of transient confusion and paralysis and was found to have symptomatic hyperviscosity. The recognition of his condition was facilitated by characteristic findings on ophthalmologic examination. He was subsequently diagnosed with Waldenström macroglobulinemia on bone marrow biopsy. Conclusions. An up to date, comprehensive review of the literature suggests an association between hepatitis C and Waldenström macroglobulinemia. Data on optimal treatment of patients with comorbid hepatitis C infection and Waldenström macroglobulinemia is limited. We have provided a comprehensive review of previously explored treatment options to guide management of other similar patients. Our patient has since been treated with repeated plasmapheresis with a plan to pursue antiviral therapy.

show abstract

Waldenström’s Macroglobulinemia Associated with Cryoglobulinemia: Pathogenetic, Clinical, and Therapeutic Aspects

Dimopoulos

2011

HCV Infection and Cryoglobulinemia

View full text Add to dashboard Cite

Leucocytoclastic vasculitis, hepatitis C virus-associated mixed cryoglobulinaemia with biclonal gammopathy and Waldenstrom macroglobulinaemia

Abstract: S . B . Á l v a r e z -R u i z I . G a r c í a -R í o M . A r a g ü é s J . F r a g a * J . L o c e r t a l e s P u e y o J . F e r n á n d e z -H e r r e r a A . G a r c í a -D í e z

Cited by 6 publications

References 12 publications

Improvement in Waldenström’s Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals

Improvement in Waldenström’s Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals

Waldenström Macroglobulinemia in Hepatitis C: Case Report and Review of the Current Literature

Waldenström’s Macroglobulinemia Associated with Cryoglobulinemia: Pathogenetic, Clinical, and Therapeutic Aspects

Contact Info

Product

Resources

About