Leucopoietic Properties of Four Different Androgenic Hormones in Irradiated Rats

Abstract

The bone marrow of irradiated rats was used to study the leucopoietic properties of 4 androgenic hormones; nortestosterone (Durabolin®), hedydroisoandrosterone (DHA), testosterone propionate and fluoxymesterone. Data were analysed to compare results in both sexes, various dosages of the hormones and differences between prophylactic and therapeutic treatment. According to the results, it was concluded that the androgenicity or anabolic property of a given hormone plays a role in its leucopoietic effect which is sex and dose dependant.

Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

“…It has been reported that AR broadly expresses in neutrophil-lineage cells from the myeloblast stage to the mature neutrophil stage with no difference in the pattern of AR expression between male and female (16). Androgen was found to stimulate proliferation of committed erythrocytic and granulocytic precursors in vitro (17)(18)(19)(20), and accelerate recovery of leukocytes after radiation or chemotherapy (21)(22)(23)(24)(25). Clinical observations with androgens in the treatment of aplastic anemia (26,27), Fanconi's anemia (28,29), and during therapy with myelosuppressive agents (30,31) suggest that androgen might increase neutrophil production.…”