Leucosceptosides A and B: Two Phenyl-Ethanoid Glycosides with Important Occurrence and Biological Activities

Frezza, Claudio; Vita, Daniela De; Toniolo, Chiara; Sciubba, Fabio; Tomassini, Lamberto; Venditti, Alessandro; Bianco, Armandodoriano; Serafini, Mauro; Foddai, Sebastiano

doi:10.3390/biom12121807

Cited by 2 publications

(1 citation statement)

References 158 publications

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“…It is derived from the base compound verbascoside and is distinguished by a methyl group in its caffeic acid moiety. It exhibits unique structural features and notable biological activities [ 125 ], including therapeutic potential against psoriasis. In an in vitro model using IFN-γ/IL-17A/IL-22-stimulated HaCaT cells, leucosceptoside A effectively mitigated psoriasis-related inflammation by suppressing the PI3K/AKT signaling pathway.…”

Section: Natural Product-derived Compounds For Psoriasis Therapeuticsmentioning

confidence: 99%

Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics

Lee,

Jung,

Choi

et al. 2024

IJMS

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Psoriasis is a chronic autoimmune inflammatory skin disorder that affects approximately 2–3% of the global population due to significant genetic predisposition. It is characterized by an uncontrolled growth and differentiation of keratinocytes, leading to the formation of scaly erythematous plaques. Psoriasis extends beyond dermatological manifestations to impact joints and nails and is often associated with systemic disorders. Although traditional treatments provide relief, their use is limited by potential side effects and the chronic nature of the disease. This review aims to discuss the therapeutic potential of keratinocyte-targeting natural products in psoriasis and highlight their efficacy and safety in comparison with conventional treatments. This review comprehensively examines psoriasis pathogenesis within keratinocytes and the various related signaling pathways (such as JAK-STAT and NF-κB) and cytokines. It presents molecular targets such as high-mobility group box-1 (HMGB1), dual-specificity phosphatase-1 (DUSP1), and the aryl hydrocarbon receptor (AhR) for treating psoriasis. It evaluates the ability of natural compounds such as luteolin, piperine, and glycyrrhizin to modulate psoriasis-related pathways. Finally, it offers insights into alternative and sustainable treatment options with fewer side effects.

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Section: Natural Product-derived Compounds For Psoriasis Therapeuticsmentioning

confidence: 99%

Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics

Lee,

Jung,

Choi

et al. 2024

IJMS

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Plant species of the genus Pedicularis L. In the territory of the Western Balkans: Overview of use in traditional medicine, phytochemistry, biological and pharmacological activity

Zubić,

Tomović

2024

Kragujevac J Science

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Modern pharmacotherapy is based on chemical substances derived from plants and herbal medicine from the past. Pedicularis L. is one of the largest genera of hemiparasitic flowering plants, with over 500 species known. It is mostly found in the cold highlands of the northern hemisphere. Numerous endemic Pedicularis species may be found in the Balkans, demonstrating their significance in plant endemism. However, several of these species may face conservation issues due to human activities like habitat fragmentation, agricultural development, and other pressures. Monitoring their numbers, protecting their habitat, and increasing public understanding of their significance are the goals of conservation initiatives. By conducting field surveys and molecular analysis to comprehend their evolutionary relationships, researchers are still working to improve the taxonomic classifications of Balkan Pedicularis species. The chemicals from Pedicularis plant species that have been identified so far have been shown to have anti-tumor, hepatoprotective, immunomodulatory, anti-inflammatory, antidiabetic, antibacterial, antifungal, analgesic, and diuretic properties in research published in the literature. This paper provides an overview of previous research in the Western Balkans.

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Leucosceptosides A and B: Two Phenyl-Ethanoid Glycosides with Important Occurrence and Biological Activities

Cited by 2 publications

References 158 publications

Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics

Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics

Plant species of the genus Pedicularis L. In the territory of the Western Balkans: Overview of use in traditional medicine, phytochemistry, biological and pharmacological activity

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