Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?

Roman, Eve; Ansell, Pat; Bull, Diana

doi:10.1038/bjc.1997.399

Cited by 129 publications

(114 citation statements)

References 52 publications

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“…20 Our findings for lymphatic cancers are similar to those found in children, e.g., for acute myeloid leukemia. 21 Women who were small at birth were at an increased risk of endometrial cancer in this study. Without any directly comparable studies with independent consistent results, there remains the possibility that this may be a chance finding.…”

Section: Comparisons With Other Studiesmentioning

confidence: 50%

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

McCormack

dos‐Santos‐Silva

Koupil

et al. 2005

Intl Journal of Cancer

121

115

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Associations between larger size at birth and increased rates of adult cancer have been proposed but few empirical studies have examined this hypothesis. We investigated overall and site-specific cancer incidence in relation to birth characteristics in a Swedish population-based cohort of 11,166 singletons born in 1915-1929 for whom we have detailed obstetric data and who were alive in 1960. A total of 2,685 first primary cancers were registered during follow-up from 1960 to 2001. A standard deviation (SD) increase in birth weight for gestational age (GA) was associated with (sexadjusted) increases of 13% (95% CI = 0.03-0.23) in the rates of digestive cancers and of 17% (95% CI = 0.01-0.35) in the rates of lymphatic cancers. Women who had higher birth weights also had increased rates of breast cancer under age 50 years (by 39% per SD increase; 95% CI = 0.09-0.79), but reduced rates (by 24%; 95% CI = 0.07-0.38) of endometrial (corpus uteri) cancer at all ages. There was no evidence of associations with other cancer sites. For overall cancer incidence, men had an 8% increased risk at all ages per SD increase in birth weight for GA while women only had an increased risk under age 50 years (mainly driven by the association with breast cancer). These findings provide evidence of a modest association of birth size and adult cancer risk, resulting from positive associations with a few cancer sites and a possible inverse association with endometrial cancer. ' 2005 Wiley-Liss, Inc.

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Section: Comparisons With Other Studiesmentioning

confidence: 50%

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

McCormack

dos‐Santos‐Silva

Koupil

et al. 2005

Intl Journal of Cancer

121

115

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“…vitamin K is not new -concerns having been expressed about the proven association between Synkavit (vitamin K 2 ) and kernicterus, documented cases of babies given oxytocics intended for the mother, and the use of unlicensed oral preparations. Indeed, even before the childhood cancer controversy such debate -enhanced by the growth of the natural childbirth movement -had resulted in marked variations between the policies of individual clinicians Epidemiology Table 5 Centre specific odds ratios (OR) and 95% confidence intervals (CI) for intramuscular vitamin K, unadjusted and adjusted for mode of delivery, admission to special care baby unit and low birth weight Ansell et al, 1996;Roman et al, 1997;4 Passmore et al, 1998a;5 McKinney et al, 1998;6 Parker et al, 1998.…”

Section: Discussionmentioning

confidence: 99%

“…vitamin K prophylaxis became a controversial topic when Golding et al (1992) reported that children who received it by this route were almost three times as likely to develop leukaemia as children who received it orally or not at all. Although subsequent studies failed to confirm these findings (Ekelund et al, 1993;Klebanoff et al, 1993;Olsen et al, 1994;Ansell et al, 1996;von Kries et al, 1996;Roman et al, 1997;McKinney et al, 1998;Parker et al, 1998;Passmore et al, 1998a,b), inconsistencies in their results have left lingering doubts about the safety of I.M. administration (Kaufman, 1999).…”

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confidence: 99%

“…In order to investigate this topic in more depth, a pooled analysis of individual patient data from the six major case -control studies (Golding et al, 1992;Ansell et al, 1996;von Kries et al, 1996;Roman et al, 1997;McKinney et al, 1998;Parker et al, 1998;Passmore et al, 1998a) has been undertaken. The principal aims were to use consistent definitions of exposure and potential confounders to:…”

mentioning

confidence: 99%

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Vitamin K and childhood cancer: analysis of individual patient data from six case–control studies

et al. 2002

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To investigate the hypothesis that neonates who receive intramuscular vitamin K are at an increased risk of developing cancer, particularly leukaemia, a pooled analysis of individual patient data from six case -control studies conducted in Great Britain and Germany has been undertaken. Subjects comprised 2431 case children diagnosed with cancer before 15 years of age and 6338 control children. The retrospective assessment of whether or not an individual baby received vitamin K is not straightforward. In many cases no record was found in stored medical notes and two types of analysis were therefore conducted; in the first it was assumed that where no written record of vitamin K was found it had not been given, and in the second, where no written record of administration was found, information on hospital policy and perinatal morbidity was used to 'impute' whether or not vitamin K had been given. In the first analysis, no association was found between neonatal administration of intramuscular. vitamin K and childhood cancer: odds ratios adjusted for mode of delivery, admission to special care baby unit and low birth weight were 1.09 (95% confidence interval 0.92 -1.28) for leukaemia and 1.05 (0.92 -1.20) for other cancers. In the second analysis, the adjusted odds ratios increased to 1.21 (1.02 -1.44) for leukaemia and 1.10 (0.95 -1.26) for other cancers. This shift did not occur in all studies, and when data from the hypothesis generating Bristol study were excluded, the adjusted odds ratios for leukaemia became 1.06 (0.89 -1.25) in the first analysis and 1.16 (0.97 -1.39) when data on prophylaxis imputed from hospital policy and perinatal morbidity were used. We conclude that whilst the broad nature of the diagnostic groups and the poor quality of some of the vitamin K data mean that small effects cannot be entirely ruled out, our analysis provides no convincing evidence that intramuscular vitamin K is associated with childhood leukaemia.

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“…This possible association has been studied for melanoma (Andersson et al, 2001;McCormack et al, 2005;Ahlgren et al, 2007) and other types of cancer (Le Marchand et al, 1988;Tibblin et al, 1995;Roman et al, 1997;Wanderås et al, 1998;Vatten et al, 2002;Hjalgrim et al, 2004;Nilsen et al, 2005;Michos et al, 2007). The results are inconclusive; however, there seems to be an association between birth weight and the risk for some cancer forms.…”

mentioning

confidence: 99%

Birth weight and melanoma risk: a population-based case–control study

et al. 2007

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We investigated whether lower birth weight was associated with lower risk of melanoma later in life. This population-based case–control study included all incident cases of histologically verified invasive melanoma diagnosed until 31 December 2003 in the Norwegian population born between 1967 and 1986 ( n =709). The control group without malignant disease was established by random sampling from the same source population as the cases ( n =108 209). Data on birth weight, gender, mother's residence and parental age at the time of birth were collected from the Medical Birth Registry of Norway and data on cancer from the Cancer Registry of Norway. The Mantel–Haenszel test of linear trend showed no trend in risk across the birth weight categories: individuals in the highest quartile of birth weight (⩾3860 g) had an odds ratio (OR) of 1.19 (95% confidence interval, CI: 0.77–1.84) compared to individuals with birth weight <2500 g. The adjusted OR was 0.81 (95% CI: 0.52–1.26) for birth weight below 2500 g (exposed). Though not statistically significant, the results suggest that low birth weight might influence the risk of melanoma later in life.

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Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?

Cited by 129 publications

References 52 publications

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

Vitamin K and childhood cancer: analysis of individual patient data from six case–control studies

Birth weight and melanoma risk: a population-based case–control study

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