2005
DOI: 10.1530/rep.1.00304
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Leukaemia inhibitory factor in implantation and uterine biology

Abstract: Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 years after publication of the phenotype of the LIF knockout mouse we are only just beginning to understand how LIF functions in the uterus. This review addresses our knowledge of the role of LIF in regulating implantation through its influence on the luminal epithelium and stromal decidualization, but also its influence … Show more

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Cited by 148 publications
(123 citation statements)
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“…LIF plays an important role in the establishment of pregnancy by supporting decidual and placental differentiation and by influencing reproductive tract cells, such as leukocytes and luminal/glandular epithelial cells. 25 The best evidence that LIF may play a role in the regulation of Mws comes from data obtained from LIF KO mice, which present a more than half reduced percentage of uterine Mws by days 3-5 of pregnancy. 25 The LIF KO mouse model also revealed the central regulatory role of LIF in endotoxic shock and host defense.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…LIF plays an important role in the establishment of pregnancy by supporting decidual and placental differentiation and by influencing reproductive tract cells, such as leukocytes and luminal/glandular epithelial cells. 25 The best evidence that LIF may play a role in the regulation of Mws comes from data obtained from LIF KO mice, which present a more than half reduced percentage of uterine Mws by days 3-5 of pregnancy. 25 The LIF KO mouse model also revealed the central regulatory role of LIF in endotoxic shock and host defense.…”
Section: Introductionmentioning
confidence: 99%
“…25 The best evidence that LIF may play a role in the regulation of Mws comes from data obtained from LIF KO mice, which present a more than half reduced percentage of uterine Mws by days 3-5 of pregnancy. 25 The LIF KO mouse model also revealed the central regulatory role of LIF in endotoxic shock and host defense. Essentially, LIF expression following endotoxic shock enhances the expression of hepatic acute-phase proteins and IL-10, which downregulates TNF-a synthesis and release in the liver, conferring protection against endotoxemia.…”
Section: Introductionmentioning
confidence: 99%
“…The factors required to promote differentiation and proliferation of EVT are unknown but may include interaction with extracellular matrix proteins and growth factors such as epidermal growth factor (EGF), leukemia inhibitory factor (LIF), bone morphogenetic factor-4 (BMP4), and fibroblast growth factor-4 (FGF4) (2)(3)(4)(5). EVT invade decidual tissue and interact with maternal decidual natural killer cells (dNK), decidual macrophages (dMϕ), and decidual T cells (dT) (1,6).…”
mentioning
confidence: 99%
“…The same observations were made when celecoxib and aspirin (selective inhibitors of COX-2 and COX-1, respectively) were used in wildtype mice (29). Based on these results, one of the mechanisms implicated in decidualization could be the action of PGE 2 and prostacyclin (PGI 2 ) through production of cytokines and growth factors (30).…”
Section: The Peri-implantatory Endometrial Changesmentioning
confidence: 53%