Leukaemia inhibitory factor (LIF) gene mutations in women with unexplained infertility and recurrent failure of implantation after IVF and embryo transfer

Steck, Theodore L.; Giess, Ralf; Suetterlin, Marc W; Bolland, Monika; Wiest, Stephanie; Poehls, Uwe; Dietl, Johannes

doi:10.1016/s0301-2115(03)00315-4

Cited by 90 publications

(54 citation statements)

References 27 publications

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“…The presence of a null allele for the most common HLA-G isoform as well as distinct polymorphisms in the HLA-G promoter region, have been associated with recurrent miscarriage, suggesting that a functional protein is necessary for reproduction (Aldrich et al 2001;Pfeiffer et al 2001). Polymorphisms in genes including p53, p72, leukemia inhibiting factor (LIF), FAS-L, and the vascular endothelial growth factor (VEGF) gene have also been linked to increased rates of implantation failure and are undergoing investigation to determine their potential roles in women with RPL (Dumont et al 2003;Steck et al 2004;Brooks et al 2007;Hu et al 2007;Goodman et al 2008;Banzato et al 2013;Fraga et al 2014). Despite evidence linking various polymorphisms in immune-related genes to pregnancy loss, these tests are not presently recommended as routine…”

Section: Single Gene Defectsmentioning

confidence: 99%

Genetic Considerations in Recurrent Pregnancy Loss

Hyde

Schust

2015

Cold Spring Harbor Perspectives in Medicine

119

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Section: Single Gene Defectsmentioning

confidence: 99%

Genetic Considerations in Recurrent Pregnancy Loss

Hyde

Schust

2015

Cold Spring Harbor Perspectives in Medicine

119

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“…Women with previously unexplained infertility were found to have point mutations in functionally important regions of LIF (Giess et al 1999). Although subsequent studies have shown point mutations on LIF to be rare (Steck et al 2004), other evidence shows a statistically significant percentage of women with unexplained fertility have reduced levels of LIF compared with control counterparts in uterine flushes during the window of implantation (Laird et al 1997).…”

Section: Leukemia Inhibitory Factor (Lif)mentioning

confidence: 99%

Animal models of implantation

Lee

DeMayo²

2004

Reproduction

240

155

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Implantation is an intricately timed event necessary in the process of viviparous birth that allows mammals to nourish and protect their young during early development. Human implantation begins when the blastocyst both assumes a fixed position in the uterus and establishes a more intimate relationship with the endometrium. Due to the impracticalities of studying implantation in humans, animal models are necessary to decipher the molecular and mechanical events of this process. This review will discuss the differences in implantation between different animal models and describe how these differences can be utilized to investigate discrete implantation stages. In addition, factors that have been shown to be involved in implantation in the human and other various animal models including growth factors, cytokines, modulators of cell adhesion, and developmental factors will be discussed, and examples from each will be given.

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“…However, today there are already some biomarkers confirmed in separate studies which are pivotial during implantation process. For example, the most potential endometrial marker identified is leukemia inhibitory factor (LIF) and its importance has been proven in animal and human studies (Stewart et al, 1994;Arici et al, 1995;Steck et al, 2004). Unfortunately, the development of recombinant human LIF (r-fLIF) has not met the expectations of increasing implantation rates in infertile women (Brinsden et al, 2009).…”

Section: Endometrial Gene Expression During the Time Of Embryo Implanmentioning

confidence: 99%