Leukemia

Kirshbaum, Jack D.; Preuss, F

doi:10.1001/archinte.1943.00210060038003

Cited by 109 publications

(5 citation statements)

References 11 publications

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“…Acute lymphatic leukaemia showed in this series a slight male preponderance (7 to 6), which is not nearly so striking as the position in the chronic lymphatic form. The virtually equal sex incidence in the cases of acute myeloid leukaemia in this series is at variance with previous views (Kirshbaum and Preuss, 1943;Whitby and Britton, 1950). Again, no significant difference was found in the sex incidence in monocytic leukaemia.…”

Section: Discussionsupporting

confidence: 64%

“…Indeed, 56 of these cases (38.8%) were child-ren under the age of 5, and 98 cases (68.1 %) occurred in the first two decades of life. The disease may, however occur at any age, as was indicated by Kirshbaum and Preuss (1943). In the present series acute myeloid leukaemia occurred over a wide range of ages (Fig.…”

Section: Discussionsupporting

confidence: 57%

“…Rosenthal and Harris (1935) noted an apparently rising annual incidence,-but discarded the idea that there was any real increase in the disease. Powell (1940) and Kirshbaum and Preuss (1943) concluded that the apparent increase was due to improvement in diagnosis. Bethell believed, however, that there had been a real and progressive increase, especially in the acute forms of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Survey of 647 Cases of Leukaemia, 1938-51

Gauld¹,

Innes²,

Robson³

1953

BMJ

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Section: Discussionsupporting

confidence: 64%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Survey of 647 Cases of Leukaemia, 1938-51

Gauld¹,

Innes²,

Robson³

1953

BMJ

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“…FORKNER (14) as well as others considered the heart and pericardium to be common sites. KIRSHBAUM and PREUSS (26), for example, reported infiltration in the hearts of 34% of their 123 patients with leukaemia, mainly acute stem cell or lymphatic leukaemia. Of the extra-lymphatic structures, the heart was second only to the kidneys (63%).…”

mentioning

confidence: 99%

Studies on the Site of Leukotic and Preleukotic Changes in the Bovine Heart

Järplid

1964

Pathologia veterinaria

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The right auricle is the primary site of leukotic changes in the bovine heart. This and other regions of the heart from 114 cattle with manifest leukosis, 44 cattle with suspected latent leukosis, 23 normal cattle, and 59 foetuses have been examined histologically. The propensity of bovine leukosis to involve the right auricle is obviously associated with the loose subepicardial connective tissue and its property of embryonal haematopoiesis. Since other mesenchymal tumours and metaplasia also involve the right auricle more often than the left, it is conceivable that the subepicardial tissue on the right side remains functionally as well as morphologically undifferentiated, and more readily responds to proliferative stimuli than does the subepicardial tissue of the left atrium, which early differentiates into fat tissue. Among the group of animals suspected of latent leukosis there were many with definite signs of leukosis in the subepicardial tissue of the right auricle. The early signs of leukosis were accumulation of lymphoid or blast-like cells, or both together, neural lymphoid infiltration, and stuffing of blood vessels with lymphocytes. The question whether the leukosis cells are formed in situ in the heart or represent metastasis from another site remains unsettled. The demonstration of a particular tissue type at the primary site of cardiac leukosis implies that further study might resolve this point and elucidate the early changes of leukosis.

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“…Symmers (1948), however, found intestinal lesions in 14 out of 40 patients with lymphoid leukaemia, and Wahl and Hill (1956) found gastric lesions in seven out of 64 patients with all types of leukaemia. When macroscopic and microscopic involvement are considered together the reported incidence of leukaemic lesions in the gastrointestinal tract becomes even higher (Kirshbaum and Preuss, 1943;Paul and Hendricks, 1948;Naruki, 1958).…”

mentioning

confidence: 99%

Leukaemic lesions of the gastrointestinal tract

Cornes

Jones

Fisher

1962

Journal of Clinical Pathology

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sYNoPsis This study is based on the clinical records and post-mortem findings of 264 patients with leukaemia. Gross leukaemic lesions in the gastrointestinal tract were found in 39 patients, an overall incidence of 14-8%. The incidence in all types of acute leukaemia was 18-4%, in chronic leukaemias 9-6 %, and in myeloid leukaemia 10-9 %. The ileum, stomach, and proximal colon were the sites most commonly affected. Four types of lesion were found: raised leukaemic nodules, leukaemic plaques, diffuse infiltrations with a convoluted brain-like appearance of the mucosal folds, and a multiple leukaemic polyposis. The clinical and pathological features of these lesions are described, and references are given to similar cases reported in the literature.

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Leukemia

Cited by 109 publications

References 11 publications

Survey of 647 Cases of Leukaemia, 1938-51

Survey of 647 Cases of Leukaemia, 1938-51

Studies on the Site of Leukotic and Preleukotic Changes in the Bovine Heart

Leukaemic lesions of the gastrointestinal tract

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