Leukemia labialis: A rare presentation of leukemia cutis limited to the lips

Obi, Chrystal; Holler, Phillip D.; Pugliese, Douglas J.; Abraham, Ronnie M.; Xu, Xiaowei; Sobanko, Joseph F.; Rosenbach, Misha; Wanat, Karolyn A.

doi:10.1016/j.jaad.2011.12.003

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…Leukemia labialis is a rare subtype of leukemia cutis that presents as multiple plaques, papules, nodules, and (rarely) ulcerative lesions confined to the lips. 1 Leukemia labialis as an initial manifestation of CLL is rare. 2 Approximately 25% of patients with CLL present with cutaneous manifestations of their disease.…”

Section: Discussionmentioning

confidence: 99%

Multiple Lip Papules and Nodules in an Adult Man

2019

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Section: Discussionmentioning

confidence: 99%

Multiple Lip Papules and Nodules in an Adult Man

2019

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“…[ 3 4 ] Moreover, there was a review showed that skin infiltration of leukemia account for 30% of all skin biopsy specimens in leukemia patients without clinic skin findings,[ 5 ] which meant the evaluation of incidence of LC may be lower than the fact. The appearances of LC are variable, including nodules, papules, plaques, and ulcers, swellings, vesicles are rare presentations, and the locations are usually the extremities, trunk, and sites of herpetic lesions,[ 3 ] intravenous catheters,[ 4 ] lips,[ 6 ] trauma and recent surgeries[ 7 ] have been reported. LC of ALL is commonly presented by single or multiple, red-to-violaceous papules or nodules on the head and neck,[ 4 ] but our case showed oval or annular scaling red patches and plaques on buttocks, thighs, and back waist, which is rare in clinic.…”

Section: Discussionmentioning

confidence: 99%

Leukemia cutis: An unusual presentation of acute lymphoblastic leukemia in a child

2015

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Leukemia cutis (LC) is a nonspecific word used for cutaneous infiltration of leukemia, which is a rare presentation of acute lymphoblastic leukemia (ALL), and always a harbinger of poor prognosis. We report a case of LC in a 5-year-old boy with a past medical history of ALL (L1) presented with multiple asymptomatic oval or annular red patches and plaques on his thighs, buttocks and back waist, and part of them were scaling lesions. A biopsy was performed and histopathological examination showed that medium-sized atypical cells with round to oval contours, scant cytoplasm, and finely dispersed chromatin infiltrated into the dermis and subcutis, and the perivascular and periadnexal areas were involved. Immunophenotyping showed that the atypical cells were positive for CD45, CD3ε, CD99, and Ki67 (about 70%). Considering the patient's medical history and the histopathology, the patient was diagnosed with LC.

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“…Although skin lesions are usually generalized, some solitary, clustered, or dispersed lesions have also been observed [2]. In rare cases, the distributions of LC can include sites of herpetic lesions, intravenous catheters, lips, trauma, and recent surgeries [7,26,27].…”

Section: Diagnosismentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

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Leukemia cutis (LC) is defined as the leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding a number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as the genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, the complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis, and treatment of leukemic skin involvement in different types of leukemia.

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Leukemia labialis: A rare presentation of leukemia cutis limited to the lips

Cited by 5 publications

References 3 publications

Multiple Lip Papules and Nodules in an Adult Man

Multiple Lip Papules and Nodules in an Adult Man

Leukemia cutis: An unusual presentation of acute lymphoblastic leukemia in a child

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

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