Leukemic iris infiltration as the only site of relapse in a child with acute lymphoblastic leukemia: Temporary remission with high‐dose chemotherapy

Abstract

A 12-year-old Caucasian boy developed leukemic hyphema with iris infiltration as the only relapse site during the third complete remission of his acute lymphoblastic leukemia. With high-dose methotrexate, high-dose cytosine-arabinoside plus teniposide, and a 5-week course of vincristine, prednisolone, and L-asparaginase, a complete remission could be achieved. Maintenance treatment was reinstituted for 1 year. However, after stopping the treatment, the iris infiltrate reappeared, and this time the eye was irradiated after chemotherapeutic reinduction. Seven months later, the boy remains in complete remission. The pathogenesis of leukemic iris infiltration is discussed briefly.

Aspectos epidemiológicos, biotipologia e evolução do tratamento da leucemia linfocítica aguda na infância e adolescência no Rio Grande do Sul

“…Tanto o comprometimento da câmara anterior como do globo ocular podem ser observados. Na câmara anterior, incluindo o envolvimento da íris, pode se manifestar sob a forma de hipopion e ou hifema 98,[254][255][256][257] .…”