Leukemic Retinopathy

Guyer, David R.; Schachat, Andrew P.; Vitale, Susan; Markowitz, Jan A.; Braine, Hayden G.; Burke, Philip J.; Karp, Judith E.; Graham, Michael

doi:10.1016/s0161-6420(89)32809-0

Cited by 90 publications

(27 citation statements)

References 16 publications

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“…In our study, a higher prevalence (49%) of leukaemic retinopathy was noted than the prevalences of 42% and 43% reported by Guyer et al (1989) and Abu el-Asrar et al (1996). Intraretinal haemorrhages and whitecentred haemorrhages were seen more often in the present study than in the above two studies.…”

Section: Discussioncontrasting

confidence: 66%

“…We observed that the mean white cell count in patients with CWS in AML and ALL groups was higher than in those without CWS, but this was not statistically significant. Abu el-Asrar et al (1996) found a significantly lower leucocyte count in patients with AML and CWS, and a non-significant higher leucocyte count in patients with ALL and CWS, while Guyer et al (1989) did not find any statistically significant association between leucocytosis and the presence of CWS.…”

Section: Discussionmentioning

confidence: 77%

“…However, Holt & Gordon-Smith (1969) and Mahneke & Videbaek (1964) felt that the white blood cell count was not related to the occurrence of WCH. Guyer et al (1989) found a non-significant trend of leucocytosis in patients with WCH. In contrast, Karesh et al (1987) observed that the number of circulating leucocytes was unrelated to the presence of haemorrhages with or without white centres.…”

Section: Discussionmentioning

confidence: 80%

“…Therefore, we feel that the correlation of haematological parameters with the occurrence of retinal lesions was appropriate. Other researchers have noted an association between anaemia and the presence of retinal haemorrhages (Gibson 1938;Culler 1954;Dwivedi et al 1986;Karesh et al 1989;Guyer et al 1989;Abu el-Asrar et al 1996). However, no significant association between anaemia and the occurrence of IRH (1996) reported that ALL patients with cotton-wool spots had significantly lower haemoglobin levels than patients without such lesions.…”

Section: Discussionmentioning

confidence: 95%

“…It is possible that the eye check-up was performed at any time during the course of illness, or only when the patient demonstrated eye symptoms, or in patients with high risk factors such as central nervous system leukaemia, severe thrombocytopenia or marked leucocytosis. Prospective studies (ophthalmic examination performed within a few days of initial diagnosis, prior to chemotherapy ntervention) on the prevalence of retinal changes in leukaemia, and their relationships with haematological parameters, are scanty in the literature (Karesh et al 1989;Guyer et al 1989;Abu el-Asrar et al 1996). Therefore, we conducted a prospective study to determine the prevalence of retinal changes in newly diagnosed, untreated patients with acute leukaemia, and to establish the relationship between fundus lesions and haematological parameters in these patients.…”

Section: Introductionmentioning

confidence: 99%

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Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

Reddy

Jackson

2003

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine the prevalence of retinal changes in newly diagnosed acute leukaemia patients, and to establish the relationship between retinal lesions and haematological parameters in these patients. Methods: A total of 127 patients with acute leukaemia (myeloid and lymphoid), of both genders, aged between 13 and 77 years, were examined by an ophthalmologist for retinal changes using direct/indirect ophthalmoscopy within 2 days of diagnosis before starting chemotherapy. Results: Retinal lesions were seen in 62 cases (49%), with intraretinal haemorrhages being the most common lesion (42%). A high white blood cell count was significantly associated with intraretinal haemorrhages (p = 0.04) and white-centred haemorrhages (p = 0.001), while a low platelet count was significantly associated with intraretinal haemorrhages (p = 0.03) in acute myeloid leukaemia patients. Conclusions: A high white blood cell count may be considered as important as a low platelet count in the pathogenesis of leukaemic retinopathy.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

Reddy

Jackson

2003

Acta Ophthalmologica Scandinavica

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The Eye in Bone Marrow Transplantation

Coskuncan

Jabs

Dunn³

et al. 1994

Arch Ophthalmol

221

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Bilateral Retinal Hemorrhages in a Young Man

2017

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A man in his 30s was referred to the retina clinic with a diagnosis of bilateral branch retinal vein occlusions. He reported flashes and progressive blurry vision in both eyes over a period of 6 days. He had no history of eye problems. His medical history was negative for diabetes and hypertension, and review of systems was positive for recent easy bruising and progressive fatigue.His initial best-corrected visual acuity was 20/25 OD and 20/50 OS. Results from examination of his pupils, motility, intraocular pressures, confrontational visual fields, and anterior segments were normal. A dilated fundus examination was conducted (Figure). He had bilateral flame-shaped and intraretinal hemorrhages in both maculae along the superior arcades and some scattered peripheral hemorrhages. There was no vessel tortuosity, and there were hard exudates in the left macula. Spectral-domain optical coherence tomography showed areas of hyperreflectivity in the middle and outer retina. Fluorescein angiography of both eyes showed blocking in the areas of hemorrhage, good venous filling, no leakage, and no neovascularization. Figure. Wide-field scanning laser image of the left eye showed superficial and intraretinal hemorrhages and hard exudates. WHAT WOULD YOU DO NEXT? A. Obtain an infectious and inflammatory panel B. Observe C. Obtain a complete blood cell count D. Inject an anti-vascular endothelial growth factor Clinical Review & Education

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Leukemic Retinopathy

Cited by 90 publications

References 16 publications

Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

Retinopathy in acute leukaemia at initial diagnosis: correlation of fundus lesions and haematological parameters

The Eye in Bone Marrow Transplantation

Bilateral Retinal Hemorrhages in a Young Man

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