Leukemoid Reactions of the Myeloid Type

Acute Tuberculosis and Granulocytic Disorders

“…The following case illustrates most of the features ordinarily regarded as being typical of a leukaemoid reaction (Heck and Hall, 1939;Emery and Lorber, 1950;Fountain, 1954;Hughes et al, 1959).…”

Ulcerative colitis complicated by a leucoerythroblastic anaemia

“…The earliest speculations included suggestions of a direct stimulus to the bone marrow by invading neoplastic cells (Hill and Duncan, 1941), but hyperplasia of the marrow tissue had been noted and an accompanying deficiency of a factor essential for normal haemopoeisis was considered likely. Intramedullary endothelial damage allowing larger immature cells to leak out into the peripheral blood has also been proposed (Hilts and Shaw, 1953), and a third mechanism suggested that immature cells in abnormal locations may be intravascular and therefore easily washed into the circulating blood (Heck and Hall, 1939). Mechanisms put forward to explain the severe leucoerythroblastic reactions seen in the presence of localized primary cancer of parenchymal organs included a selective chemotactic effect of toxic substances on an haemopoeitic cell type (Arneth, 1937), possibly a tumour product (Sonnenfield, 1929).…”

Pathology of Leukemoid Reaction of the Myeloid Type, with Special Reference to Differentiation from Myeloid Leukemia

“…4, 6), and in the latter group there were neoplasms in 5 cases (No. 2,3,5,8,12) and aplastic anemia in 2 cases (No. 19,20).…”

“…In leukemoid reaction, however, the sinuses were dilated markedly and filled with numerous (No. 3,12). erythrocytes.…”

“…In these severe cases, some foci of erythropoiesis were also observed in the cortex (No. 3,12). A small number of erythroblasts were scattered in the sinuses in one of these cases (No.…”