1997
DOI: 10.1002/jlb.61.4.489
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Leukocyte activation induces surface redistribution of P-selectin glycoprotein ligand-1

Abstract: Abstract:Binding ofP-selectin on activated endothelium to P-selectin glycoprotein ligand-1

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Cited by 105 publications
(97 citation statements)
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References 36 publications
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“…Almost all of the PSGL-1 was expressed on the surface of WT murine leukocytes ( Fig. 2A), consistent with the predominant surface expression of PSGL-1 on human leukocytes (17). Much less PSGL-1 was expressed on the surfaces of ⌬CD leukocytes ( Fig.…”
Section: Deleting the Cytoplasmic Domain Impairs Expression Of Psgl-1supporting
confidence: 75%
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“…Almost all of the PSGL-1 was expressed on the surface of WT murine leukocytes ( Fig. 2A), consistent with the predominant surface expression of PSGL-1 on human leukocytes (17). Much less PSGL-1 was expressed on the surfaces of ⌬CD leukocytes ( Fig.…”
Section: Deleting the Cytoplasmic Domain Impairs Expression Of Psgl-1supporting
confidence: 75%
“…PSGL-1 is localized on the tips of leukocyte microvilli (5) and has affinity for cholesterol-rich membrane domains or lipid rafts (15). It moves to the uropods as cells polarize after chemokine stimulation (16,17).…”
Section: On Endothelial Cells Leukocytes Then Use Integrinsmentioning
confidence: 99%
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“…Our study failed to demonstrate any association between plasma SELPLG levels and CAD risk. It has been suggested that the way SELPLG is distributed on the leukocyte surface, and not the amount, is important for adhesion of leukocytes to P-selectin (Bruehl et al 1997;Lorant et al 1995). Moreover, SELPLG in the circulation could derive either from the release of SELPLG from leukocyte surfaces or from its release after the initiation of leukocyte rolling (Davenpeck et al 2000).…”
Section: Discussionmentioning
confidence: 99%
“…O rolling é seguido da firme adesão mediada pelas β 2 -integrinas presentes nos neutrófilos e seus ligantes, membros da superfamília das imunoglobulinas (intercelular cell adhesion molecule-1 e 2 ICAM-1 e ICAM-2) presentes nas células endoteliais (BRUEHL et al, 1997;HIDALGO et al, 2007;LEY et al, 2007;KOLACZKOWSKA e KUBES, 2013;MULLER, 2013). Está descrito que o aumento da expressão das β 2 -integrinas envolve a ação das quinases, do Inositol-3-fosfato (PIP3), do diacilglicerol (DAG), além do aumento do cálcio intracelular (iCa 2+ ) (ANTHIS et al, 2009;MUELLER et al, 2010;YAGO et al, 2010).…”
Section: Pka -Proteína Quinaseunclassified