Leukocyte adhesion deficiency in a child with severe oral involvement

Majorana, Alessandra; Notarangelo, Luigi D.; Savoldi, E; Gastaldi, Giorgio; Lozada‐Nur, Francina

doi:10.1016/s1079-2104(99)70162-9

Cited by 27 publications

(16 citation statements)

References 21 publications

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“…Severe periodontitis is uncommon in children 13,14 . It is usually associated with systemic diseases such as hypophosphatasia, 15,16 Papillon‐Lefèvre syndrome, 17,18 Langerhans' cell histiocytosis, 7,8 neutropenia, 19 or leukocyte adhesion deficiency 20 . However, it has also been observed in systemically healthy children 8,14,21‐25 .…”

Section: Discussionmentioning

confidence: 99%

Langerhans' Cell Histiocytosis in a 5‐Year‐Old Girl: Evidence of Periodontal Pathogens

Torrungruang

Sittisomwong

Rojanasomsith

et al. 2006

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Langerhans' Cell Histiocytosis in a 5‐Year‐Old Girl: Evidence of Periodontal Pathogens

Torrungruang

Sittisomwong

Rojanasomsith

et al. 2006

Journal of Periodontology

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“…Clinical findings, to include periodontal, are recurrent infections without pus formation, delayed umbilical cord separation, leukocytosis, skin ulcers, and severe aggressive periodontitis that may affect the primary and permanent dentition (Meyle, ; Majorana et al , ; Cox and Weathers, ; Dababneh et al , ; Notarangelo and Badolato, ; Al‐Herz et al , ; Yashoda‐Devi et al , ; Nagendran et al , ).…”

Section: Primary Immunodeficiencies (Genetic)mentioning

confidence: 99%

Periodontal and other oral manifestations of immunodeficiency diseases

2016

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The list of immunodeficiency diseases grows each year as novel disorders are discovered, classified, and sometimes reclassified due to our ever-increasing knowledge of immune system function. Although the number of patients with secondary immunodeficiencies (SIDs) greatly exceeds those with primary immunodeficiencies (PIDs), the prevalence of both appears to be on the rise probably because of scientific breakthroughs that facilitate earlier and more accurate diagnosis. Primary immunodeficiencies in adults are not as rare as once thought. Globally, the main causes of secondary immunodeficiency are HIV infection and nutritional insufficiencies. Persons with acquired immune disorders such as AIDS caused by the Human Immunodeficiency Virus (HIV) are now living long and fulfilling lives as a result of highly active antiretroviral therapy (HAART). Irrespective of whether the patient’s immune deficient state is a consequence of a genetic defect or is secondary in nature, dental and medical practitioners must be aware of the constant potential for infections and/or expressions of autoimmunity in these individuals. The purpose of this paper is to review the most common conditions resulting from primary and secondary immunodeficiency states, how they are classified, and the detrimental manifestations of these disorders on the periodontal and oral tissues.

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“…Historically, P. aeruginosa has been a dominant pathogen during pulmonary CF infections, and has contributed to morbidity and mortality (Smith et al, 2006). P. aeruginosa is a major pathogen of multiple hosts, causes both acute and chronic infections, and has also been detected in some unique cases of periodontitis (Majorana et al, 1999). In addition to being multidrug-resistant, P. aeruginosa has the extraordinary ability to persist during an infection by altering the regulation of virulence and metabolic gene expression, with the most notable example being during CF pulmonary infections (Carmeli et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis

Scoffield

2016

Microbiology

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Pseudomonas aeruginosa is the major aetiological agent of chronic pulmonary infections in cystic fibrosis (CF) patients. However, recent evidence suggests that the polymicrobial community of the CF lung may also harbour oral streptococci, and colonization by these micro-organisms may have a negative impact on P. aeruginosa within the CF lung. Our previous studies demonstrated that nitrite abundance plays an important role in P. aeruginosa survival during co-infection with oral streptococci. Nitrite reductase is a key enzyme involved in nitrite metabolism. Therefore, the objective of this study was to examine the role nitrite reductase (gene nirS) plays in P. aeruginosa survival during co-infection with an oral streptococcus, Streptococcus parasanguinis. Inactivation of nirS in both the chronic CF isolate FRD1 and acute wound isolate PAO1 reduced the survival rate of P. aeruginosa when co-cultured with S. parasanguinis. Growth of both mutants was restored when co-cultured with S. parasanguinis that was defective for H 2 O 2 production. Furthermore, the nitrite reductase mutant was unable to kill Drosophila melanogaster during co-infection with S. parasanguinis. Taken together, these results suggest that nitrite reductase plays an important role for survival of P. aeruginosa during co-infection with S. parasanguinis.

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Leukocyte adhesion deficiency in a child with severe oral involvement

Cited by 27 publications

References 21 publications

Langerhans' Cell Histiocytosis in a 5‐Year‐Old Girl: Evidence of Periodontal Pathogens

Langerhans' Cell Histiocytosis in a 5‐Year‐Old Girl: Evidence of Periodontal Pathogens

Periodontal and other oral manifestations of immunodeficiency diseases

Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis

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