2013
DOI: 10.1038/ki.2013.2
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Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis

Abstract: Antineutrophil cytoplasm antibody (ANCA)–associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory conditions. By immunohistochemistry of renal biopsies, patients with focal or crescentic glomerular lesions were found to have the highest expression of calprotectin and those with sclerotic the … Show more

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Cited by 90 publications
(122 citation statements)
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“…NETosis has been described also in SLE (15) and rheumatoid arthritis (19), but we could not observe a significant correlation with CRP in active disease, suggesting that NET remnants and CRP at least partly indicate activity in different pathogenic pathways. Interestingly, in a recent study measuring calprotectin (present in NETs), increased levels of calprotectin in the circulation during both active disease and remission could be seen (23).…”
Section: Discussionmentioning
confidence: 99%
“…NETosis has been described also in SLE (15) and rheumatoid arthritis (19), but we could not observe a significant correlation with CRP in active disease, suggesting that NET remnants and CRP at least partly indicate activity in different pathogenic pathways. Interestingly, in a recent study measuring calprotectin (present in NETs), increased levels of calprotectin in the circulation during both active disease and remission could be seen (23).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, biomarkers that are not (necessarily) related to ANCA may also be relevant, such as markers reflecting inflammation, injury, and repair [111]. Multiple studies have already shown an association of such a biomarker [111,112], but the number of included patients restrict the analysis to the predictive value of a single biomarker. Future collaborations may increase the amount of included patients and will enable us to analyze the predictive value of a panel of biomarkers to better predict relapses.…”
Section: Expert Opinionmentioning
confidence: 99%
“…162,163 CLP serum levels correlated with disease activity but not with antineutrophil cytoplasm antibodies (ANCA), CRP or WBC. 162,163 CLP decreased during treatment but did not get back into the normal range, suggesting the persistence of subclinical inflammation.…”
Section: Antineutrophil Cytoplasm Antibody-associated Vasculitismentioning
confidence: 99%
“…162,163 CLP serum levels correlated with disease activity but not with antineutrophil cytoplasm antibodies (ANCA), CRP or WBC. 162,163 CLP decreased during treatment but did not get back into the normal range, suggesting the persistence of subclinical inflammation. 162,163 Importantly, the increase of CLP serum levels seems to predict a disease relapse with a higher likelihood than ANCA serum levels.…”
Section: Antineutrophil Cytoplasm Antibody-associated Vasculitismentioning
confidence: 99%