Leukocyte CD15 Expression and Platelet Activation in the Coronary Sinus after Coronary Intervention

Rauch, Ursula; Wolff, Ursula Maria; Schultheiss, Heinz‐Peter; Schwimmbeck, Peter L.

doi:10.1159/000073855

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…They belong to the integrin family, which are heterodimeric cell surface proteins involved in neutrophil migration and functional responses (17)(18)(19). CD15 is a carbohydrate adhesion molecule that is associated with glycoproteins, glycolipids, and proteoglycans (20,21). As a penta-saccharide, CD15 is abundant in human milk (22).…”

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confidence: 99%

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

Wang

et al. 2016

The Journal of Immunology

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Apoptosis is the most common form of neutrophil death under both physiological and inflammatory conditions. However, forms of nonapoptotic neutrophil death have also been observed. In the current study, we report that human neutrophils undergo necroptosis after exposure to GM-CSF followed by the ligation of adhesion receptors such as CD44, CD11b, CD18, or CD15. Using a pharmacological approach, we demonstrate the presence of a receptor-interacting protein kinase-3 (RIPK3)-a mixed lineage kinase-like (MLKL) signaling pathway in neutrophils which, following these treatments, first activates p38 MAPK and PI3K, that finally leads to the production of high levels of reactive oxygen species (ROS). All these steps are required for necroptosis to occur. Moreover, we show that MLKL undergoes phosphorylation in neutrophils in vivo under inflammatory conditions. This newly identified necrosis pathway in neutrophils would imply that targeting adhesion molecules could be beneficial for preventing exacerbation of disease in the neutrophilic inflammatory response.

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confidence: 99%

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

Wang

et al. 2016

The Journal of Immunology

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Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases

Lui

Brown

et al. 2007

Clinical Proteomics

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Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment?

Jaumdally

Varma

MacFadyen

et al. 2007

European Heart Journal

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Atherosclerosis remains the underlying cause of cardiovascular disease and is a dynamic process involving inflammation, haemostasis, endothelial dysfunction, and angiogenesis. Studies of circulating factors from peripheral blood can provide an insight into this pathophysiology but may remain indicative of a more generalized, systemic process. More localized interaction(s) within the heart may be better studied from coronary blood samples. Indeed, an increasing number of prospective studies show good correlation between indices of these processes and clinical outcomes. As local sampling offers a unique way of assessing the local cardiac milieu, this may prove useful in the monitoring of both local/systemic drug therapies and interventional technologies.

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Leukocyte CD15 Expression and Platelet Activation in the Coronary Sinus after Coronary Intervention

Cited by 3 publications

References 17 publications

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases

Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment?

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