Leukocyte filters: a review of the mechanisms and applications in hemotherapy

Urias, Elaine Veloso Rocha; Teles, Leandro de Freitas; Lula, Jamille Fernandes; Rocha, Caroline Urias; Pereira, Igor Alcântara; Givisiez, Flavia Naves; Viana, Agostinho Gonçalves; Soares, Tânia de Cássia Moreira; Carvalho, Sílvio Fernando Guimarães

doi:10.1590/1806-9282.20210383

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…An alternative LR filter can remove 99% leukocytes in the blood. 9 The decision to perform LR transfusion was at the clinician’s discretion. The goal of LR transfusion could be achieved by pre-storage LR blood cell products or adoption of an LR filter.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience

2023

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Objective To assess the spectrum of patients who developed recurrent acute transfusion reactions (TRs) and to characterize these recurrent TRs. Methods This retrospective study included patients who developed ≥2 acute TRs between April 2017 and March 2020 in a tertiary medical centre. Results Among 216 TRs that occurred after 2024 transfusions in 87 patients, 66 (75.9%) patients reported a history of transfusions before the first TR and 70 (80.5%) patients received further transfusions after the last TR; with the same type of TR and reaction to the same type of blood product observed in 59 (67.8%) patients and 56 (64.4%) patients, respectively. TRs were most commonly associated with packed red blood cell (PRBC) transfusions and a febrile non-haemolytic transfusion reaction (FNHTR) was the most common type of TR. However, leukocyte reduced (LR) PRBCs were less common than LR platelets among transfusions with TR (22.7% [27/119] versus 75.0% [57/76], respectively) and premedication was prescribed before 196 of 216 (90.7%) transfusions with TR. Conclusion Most patients with recurrent TRs received repeated transfusions in addition to transfusions with TR. Instead of considering premedication, an increase in the use of LR might be the strategy to reduce the recurrence of TR.

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Section: Methodsmentioning

confidence: 99%

Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience

2023

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“…[ 25 ] They have pores ranging from 5 to 50 mm and are able to meet current hemocomponents’ quality standards. [ 26 ]…”

Section: Leukocyte-poor Packed Red Blood Cells and Platelet Concentratesmentioning

confidence: 99%

Human leukocyte antigen alloimmunization prevention mechanisms in blood transfusion

Adane¹,

Enawgaw²

2022

Asian Journal of Transfusion Science

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In many fields of clinical medicine and blood transfusion, the human leukocyte antigen (HLA) system is crucial. Alloimmunization happens as a result of an immune response to foreign antigens encountered during blood transfusion. This gives rise to alloantibodies against red blood cells (RBCs), HLA, or human platelet antigen (HPA). HLA alloimmunization following allogeneic transfusion was shown to be a result of contaminating white blood cells (WBCs) present in the product. It is a common complication of transfusion therapy that leads to difficulties in clinical intolerance and refractoriness to platelet transfusion during patient management. Single-donor platelets, prophylactic HLA matching, leukoreduction, and irradiation of cellular blood products are some of the mechanisms to prevent HLA alloimmunization during a blood transfusion. Now, the best approach to reduce the occurrence of primary HLA alloimmunization is the removal of WBCs from the blood by filtration.

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Reassessing blood product irradiation in haploidentical transplantation: a single-center perspective

Martínez-Hernández,

López-Mora,

Salazar-Riojas

et al. 2024

Hematology

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Leukocyte filters: a review of the mechanisms and applications in hemotherapy

Cited by 3 publications

References 24 publications

Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience

Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience

Human leukocyte antigen alloimmunization prevention mechanisms in blood transfusion

Reassessing blood product irradiation in haploidentical transplantation: a single-center perspective

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