Leukocyte Function in Chronic Myeloproliferative Disorders

Wolach, Baruch; Gavrieli, Ronit; Manor, Yosef; Lishner, Michael

doi:10.1006/bcmd.1998.0218

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…We showed that PMA-triggered ROS production was reduced in patients harbouring a profound impairment in NET formation, indicating that this defect lies, at least in part, at the step of ROS production, which may be due in turn to defective signals upstream of ROS, as suggested by the finding of reduced ERK1/2 phosphorylation. A more comprehensive study of other phagocytic functions may help determine whether neutrophil function is altered in MPN, particularly in MF patients, as suggested by previous findings41.…”

Section: Discussionmentioning

confidence: 77%

Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms

Oyarzún

Carestia

Lev

et al. 2016

Sci Rep

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The mechanisms underlying increased thrombotic risk in chronic myeloproliferative neoplasms (MPN) are incompletely understood. We assessed whether neutrophil extracellular traps (NETs), which promote thrombosis, contribute to the procoagulant state in essential thrombocythemia, polycythemia vera and myelofibrosis (MF) patients. Although MPN neutrophils showed increased basal reactive oxygen species (ROS), enhanced NETosis by unstimulated neutrophils was an infrequent finding, whereas PMA-triggered NETosis was impaired, particularly in MF, due to decreased PMA-triggered ROS production. Elevated circulating nucleosomes were a prominent finding and were higher in patients with advanced disease, which may have potential prognostic implication. Histone-MPO complexes, proposed as specific NET biomarker, were seldomly detected, suggesting NETs may not be the main source of nucleosomes in most patients, whereas their correlation with high LDH points to increased cell turn-over as a plausible origin. Lack of association of nucleosomes or NETs with thrombosis or activation markers does not support their use as predictors of thrombosis although prospective studies in a larger cohort may help define their potential contribution to MPN thrombosis. These results do not provide evidence for relevant in vivo NETosis in MPN patients under steady state conditions, although availability of standardized NET biomarkers may contribute to further research in this field.

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Section: Discussionmentioning

confidence: 77%

Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms

Oyarzún

Carestia

Lev

et al. 2016

Sci Rep

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“…[3][4][5][6][7][8][9] However, in none of these studies was a comparison made between patients with myeloproliferative disease with and without thrombosis. Arellano-Rodrigo et al first analyzed leukocyte and platelet activation in ET patients with and without thrombosis, showing an increased percentage of platelets that expressed P-selectin, as well as overexpression of the monocyte CD11b antigen in patients with thrombosis, 10 which suggests that the activation of the platelets and leukocytes (and, notably, the monocytes) could be involved in the genesis of the thrombosis of this disease ( Table 1).…”

Section: Leukocyte and Platelet Activation And The Thrombosis Of Myelmentioning

confidence: 99%

Blood cell activation in myeloproliferative neoplasms

Cervantes¹,

Arellano‐Rodrigo²,

Alvarez‐Larrán³

2009

Haematologica

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“…There are not many scientific articles in the literature that examine leukocyte function in Ph-negative MPDs. In a 1998 study, Wolach et al [14] examined neutrophil chemotaxis, bactericidal activity and superoxide anion release in cohorts of patients affected by CML, polycythemia vera and essential thrombocythemia, compared to a cohort of normal controls. The essential thrombocythemia population was the only one in which no disturbance of any of the functions examined was present.…”

Section: Discussionmentioning

confidence: 99%

Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemia

Lapecorella¹,

Lucchesi²,

Ianni³

et al. 2010

Blood Coagulation & Fibrinolysis

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Essential thrombocythemia is a hematological disorder characterized by clonal hemopoiesis in the bone marrow and increased number of circulating platelets. It is usually discovered accidentally at the time of routine blood examinations or can become clinically evident with either thrombotic or hemorrhagic complications. In the present article, we describe the case of a 66-year-old woman with pneumonia due to Pneumocystis carinii, who experienced deep vein thrombosis and pulmonary embolism during hospitalization with a subsequent heparin-induced thrombocytopenia. Bone marrow examination performed after clinical improvement revealed the patient to be affected by essential thrombocythemia.

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Leukocyte Function in Chronic Myeloproliferative Disorders

Cited by 14 publications

References 19 publications

Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms

Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms

Blood cell activation in myeloproliferative neoplasms

Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemia

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