Leukocyte‐Poor CPD Blood

Frey-Wettstein, M; Bachmann, Marlies

doi:10.1111/j.1423-0410.1974.tb02385.x

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Testosterone has important suppressive effects on the thymus both in utero and after birth (31,32). Thus, during periods of increased testosterone effects on left brain development, maturation of the immune system is also likely to be affected.…”

Section: Discussionmentioning

confidence: 99%

Left-handedness: association with immune disease, migraine, and developmental learning disorder.

Geschwind¹,

Behan²

1982

Proc. Natl. Acad. Sci. U.S.A.

1,065

394

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We report an experimental study designed to test the following hypothesis derived from clinical observations: There is an elevated frequency in left-handed individuals and in their families of immune disease, migraine, and developmental learning disorders. In two separate investigations the frequency ofthese conditions was compared -in strongly left-handed subjects and -in strongly right-handed controls. In each of the investigations we found markedly higher frequencies of immune disease in the lefthanders than in the rightphanders. The rate of learning disabilities was also much higher in the left-handers than in the right-handers in both investigations. In a second study the frequency of lefthandedness was compared in patients with migraine or immune disease and in general population control subjects free of these disorders. There was' a higher frequency of left-handedness in patients with migraine and myasthenia gravis than in controls. We present a brief outline of a hypothesis that may account for an increased frequency of immune disease in left-handers and in their families.Cerebral dominance-i. e., greater proficiency ofeach cerebral hemisphere in acquisition and performance of certain specific functions-has been recognized as a biological characteristic of humans' for over 100 years. In most people there is dominance ofthe left hemisphere for language and ofthe right side for certain spatial functions. The older literature dealt predominantly with humans, with major stress on the laterality of lesions producing certain cognitive deficits. Since World War H' there have been many studies that demonstrate dominance in normals.By contrast, few studies on laterality deal with the kinds of data that are often found in studies ofother biological traits, such as eye color. Examples of such data include the anatomical structures involved, biochemical and' immunological properties, genetics, ontogeny, evolution, and comparative features in other species. In older publications one finds a few discussions ofassociations ofhandedness, such as asymmetries in fingerprints (1). More recent studies deal with anatomical asymmetries in the human brain, especially in language areas (2-6), asymmetries of function and structure in other species (7-11), the genetics of handedness (10, 12, 13), and the relationship of sinistrality to learning disabilities and to artistic, athletic, and other -talents (12,14). Anatomical maldevelopment has been demonstrated in the left side of the cortex (15) and in the thalamus (16) of a left-handed childhood dyslexic. These studies reflect growing interest in the' biological associations of dominance.Since the autumn of 1980, one of us (N.G.) has been impressed by observations on both patients and normals with an apparently elevated frequency ofcertain disorders in left-handers and in their families, including immune disorders (e.g., ulcerative colitis, celiac disease, and Hashimoto's thyroiditis) and migraine. Developmental learning disorders (e. g., dyslexia and stuttering) were als...

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Section: Discussionmentioning

confidence: 99%

Left-handedness: association with immune disease, migraine, and developmental learning disorder.

Geschwind¹,

Behan²

1982

Proc. Natl. Acad. Sci. U.S.A.

1,065

394

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Supportive Therapie der Knochenmarksinsuffizienz Technische, immunologische und klinische Entwicklungen

1975

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Supportive care with blood component transfusions has greatly improved prognosis in patients with bone marrow failure. This progress has made possible by newly developed techniques for separation of blood cells and by a better understanding of the antigenicity of human blood cells and of immunologic reactions following their transfusion. Transfusion of white cell and platelet-poor red cell preparations prevent alloimmunization to leukocyte and platelet-bound alloantigens, or non-hemolytic transfusion reactions in already alloimmunized patients. Alloimmunization can be circumvened and effective long-term platelet support to thrombocytopenic patients can be provided by matching donor and recipient for HL-A antigens. The place of granulocyte transfusion in clinical therapy has yet to be defined, although their usefulness in infected granulocytopenic patients is suggested by the few studies reported so far.

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Delayed alloimmunization using random single donor platelet transfusions: a prospective study in thrombocytopenic patients with acute leukemia

Gmür

Felten

Osterwalder

et al. 1983

Blood

135

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A randomized study was performed in 54 thrombocytopenic patients with acute leukemia. Alloimmunization of recipients of random multiple-donor platelet concentrates (MD group) was compared to that of patients receiving random single-donor platelets (SD group). In the SD patients, formation of alloantibodies (mostly anti-HLA) occurred less frequently (p less than 0.002), after a longer time period (p less than 0.002), and after a higher number of transfusions (p less than 0.005) as compared to MD patients. SD patients also became refractory to random platelets less frequently (p less than 0.005), after a longer time period, and after a higher number of transfusions (p less than 0.02). In SD patients, the increments after the first and the last transfusion were in the same range, whereas in MD patients, the 1-hr (p less than 0.001) and the 24-hr (p less than 0.025) increments decreased from the first to the last transfusion. Thus, the use of random SD platelet transfusions postponed alloimmunization.

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Leukocyte‐Poor CPD Blood

Cited by 4 publications

References 12 publications

Left-handedness: association with immune disease, migraine, and developmental learning disorder.

Left-handedness: association with immune disease, migraine, and developmental learning disorder.

Supportive Therapie der Knochenmarksinsuffizienz Technische, immunologische und klinische Entwicklungen

Delayed alloimmunization using random single donor platelet transfusions: a prospective study in thrombocytopenic patients with acute leukemia

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